A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis

A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis

Abstract Background Hypomethylation of the cathepsin Z locus has been proposed as an epigenetic risk factor for multiple sclerosis (MS). Cathepsin Z is a unique lysosomal cysteine cathepsin expressed primarily by antigen presenting cells. While cathepsin Z expression has been associated with neuroin...

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Bibliographic Details
Main Authors: Euan R. O. Allan, Rhiannon I. Campden, Benjamin W. Ewanchuk, Pankaj Tailor, Dale R. Balce, Neil T. McKenna, Catherine J. Greene, Amy L. Warren, Thomas Reinheckel, Robin M. Yates
Format: Article
Language:English
Published: BioMed Central 2017-05-01
Series:Journal of Neuroinflammation
Subjects:
Multiple Sclerosis
Experimental Autoimmune Encephalomyelitis
NLRP3 Inflammasome
Inflammasome Activation
Experimental Autoimmune Encephalomyelitis Induction
Online Access:http://link.springer.com/article/10.1186/s12974-017-0874-x

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http://link.springer.com/article/10.1186/s12974-017-0874-x

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