The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC

Abstract Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the study protocol and even what the role of Diffusion-weighted imaging (DWI). The pos...

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Main Authors:	Vincenza Granata, Roberta Fusco, Salvatore Filice, Orlando Catalano, Mauro Piccirillo, Raffaele Palaia, Francesco Izzo, Antonella Petrillo
Format:	Article
Language:	English
Published:	BioMed Central 2018-07-01
Series:	Infectious Agents and Cancer
Subjects:	HCC Magnetic resonance imaging Diffusion weighted imaging Histologic grade
Online Access:	http://link.springer.com/article/10.1186/s13027-018-0194-5

id	doaj-art-3216eea292ef41f6b392c5fdaa676d70
recordtype	oai_dc
spelling	doaj-art-3216eea292ef41f6b392c5fdaa676d702018-08-15T22:42:12ZengBioMed CentralInfectious Agents and Cancer1750-93782018-07-011311610.1186/s13027-018-0194-5The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCCVincenza Granata0Roberta Fusco1Salvatore Filice2Orlando Catalano3Mauro Piccirillo4Raffaele Palaia5Francesco Izzo6Antonella Petrillo7Radiology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliRadiology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliRadiology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliRadiology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliHepatobiliary Surgical Oncology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliHepatobiliary Surgical Oncology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliHepatobiliary Surgical Oncology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliRadiology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliAbstract Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the study protocol and even what the role of Diffusion-weighted imaging (DWI). The possibility that imaging study can correlate to histologic grade to selecting the therapeutic strategy would be valuable in helping to direct the proper management of HCC. Apparent Diffusion Coefficient (ADC) and IVIM-derived perfusion fraction (fp) and tissue diffusivity (Dt) values of HCC showed significantly better diagnostic performance in differentiating high-grade HCC from low-grade HCC, and significant correlation was observed between ADC, fp, Dt and histological grade.http://link.springer.com/article/10.1186/s13027-018-0194-5HCCMagnetic resonance imagingDiffusion weighted imagingHistologic grade
institution	Open Data Bank
collection	Open Access Journals
building	Directory of Open Access Journals
language	English
format	Article
author	Vincenza Granata Roberta Fusco Salvatore Filice Orlando Catalano Mauro Piccirillo Raffaele Palaia Francesco Izzo Antonella Petrillo
spellingShingle	Vincenza Granata Roberta Fusco Salvatore Filice Orlando Catalano Mauro Piccirillo Raffaele Palaia Francesco Izzo Antonella Petrillo The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC Infectious Agents and Cancer HCC Magnetic resonance imaging Diffusion weighted imaging Histologic grade
author_facet	Vincenza Granata Roberta Fusco Salvatore Filice Orlando Catalano Mauro Piccirillo Raffaele Palaia Francesco Izzo Antonella Petrillo
author_sort	Vincenza Granata
title	The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC
title_short	The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC
title_full	The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC
title_fullStr	The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC
title_full_unstemmed	The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC
title_sort	current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of hcc
publisher	BioMed Central
series	Infectious Agents and Cancer
issn	1750-9378
publishDate	2018-07-01
description	Abstract Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the study protocol and even what the role of Diffusion-weighted imaging (DWI). The possibility that imaging study can correlate to histologic grade to selecting the therapeutic strategy would be valuable in helping to direct the proper management of HCC. Apparent Diffusion Coefficient (ADC) and IVIM-derived perfusion fraction (fp) and tissue diffusivity (Dt) values of HCC showed significantly better diagnostic performance in differentiating high-grade HCC from low-grade HCC, and significant correlation was observed between ADC, fp, Dt and histological grade.
topic	HCC Magnetic resonance imaging Diffusion weighted imaging Histologic grade
url	http://link.springer.com/article/10.1186/s13027-018-0194-5
_version_	1612702871698014208

The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC

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