The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC

Abstract Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the study protocol and even what the role of Diffusion-weighted imaging (DWI). The pos...

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Main Authors: Vincenza Granata, Roberta Fusco, Salvatore Filice, Orlando Catalano, Mauro Piccirillo, Raffaele Palaia, Francesco Izzo, Antonella Petrillo
Format: Article
Language:English
Published: BioMed Central 2018-07-01
Series:Infectious Agents and Cancer
Subjects:
HCC
Online Access:http://link.springer.com/article/10.1186/s13027-018-0194-5
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spelling doaj-art-3216eea292ef41f6b392c5fdaa676d702018-08-15T22:42:12ZengBioMed CentralInfectious Agents and Cancer1750-93782018-07-011311610.1186/s13027-018-0194-5The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCCVincenza Granata0Roberta Fusco1Salvatore Filice2Orlando Catalano3Mauro Piccirillo4Raffaele Palaia5Francesco Izzo6Antonella Petrillo7Radiology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliRadiology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliRadiology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliRadiology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliHepatobiliary Surgical Oncology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliHepatobiliary Surgical Oncology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliHepatobiliary Surgical Oncology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliRadiology Division, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS di NapoliAbstract Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the study protocol and even what the role of Diffusion-weighted imaging (DWI). The possibility that imaging study can correlate to histologic grade to selecting the therapeutic strategy would be valuable in helping to direct the proper management of HCC. Apparent Diffusion Coefficient (ADC) and IVIM-derived perfusion fraction (fp) and tissue diffusivity (Dt) values of HCC showed significantly better diagnostic performance in differentiating high-grade HCC from low-grade HCC, and significant correlation was observed between ADC, fp, Dt and histological grade.http://link.springer.com/article/10.1186/s13027-018-0194-5HCCMagnetic resonance imagingDiffusion weighted imagingHistologic grade
institution Open Data Bank
collection Open Access Journals
building Directory of Open Access Journals
language English
format Article
author Vincenza Granata
Roberta Fusco
Salvatore Filice
Orlando Catalano
Mauro Piccirillo
Raffaele Palaia
Francesco Izzo
Antonella Petrillo
spellingShingle Vincenza Granata
Roberta Fusco
Salvatore Filice
Orlando Catalano
Mauro Piccirillo
Raffaele Palaia
Francesco Izzo
Antonella Petrillo
The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC
Infectious Agents and Cancer
HCC
Magnetic resonance imaging
Diffusion weighted imaging
Histologic grade
author_facet Vincenza Granata
Roberta Fusco
Salvatore Filice
Orlando Catalano
Mauro Piccirillo
Raffaele Palaia
Francesco Izzo
Antonella Petrillo
author_sort Vincenza Granata
title The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC
title_short The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC
title_full The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC
title_fullStr The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC
title_full_unstemmed The current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of HCC
title_sort current role and future prospectives of functional parameters by diffusion weighted imaging in the assessment of histologic grade of hcc
publisher BioMed Central
series Infectious Agents and Cancer
issn 1750-9378
publishDate 2018-07-01
description Abstract Hepatocellular carcinoma (HCC) is one of the most common human solid malignancies worldwide. Although the MRI is the technique that is best adapted to characterize HCC, there is not an agreement regarding the study protocol and even what the role of Diffusion-weighted imaging (DWI). The possibility that imaging study can correlate to histologic grade to selecting the therapeutic strategy would be valuable in helping to direct the proper management of HCC. Apparent Diffusion Coefficient (ADC) and IVIM-derived perfusion fraction (fp) and tissue diffusivity (Dt) values of HCC showed significantly better diagnostic performance in differentiating high-grade HCC from low-grade HCC, and significant correlation was observed between ADC, fp, Dt and histological grade.
topic HCC
Magnetic resonance imaging
Diffusion weighted imaging
Histologic grade
url http://link.springer.com/article/10.1186/s13027-018-0194-5
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