Heterologous expression of cytotoxic sesquiterpenoids from the medicinal mushroom Lignosus rhinocerotis in yeast

Heterologous expression of cytotoxic sesquiterpenoids from the medicinal mushroom Lignosus rhinocerotis in yeast

Abstract Background Genome mining facilitated by heterologous systems is an emerging approach to access the chemical diversity encoded in basidiomycete genomes. In this study, three sesquiterpene synthase genes, GME3634, GME3638, and GME9210, which were highly expressed in the sclerotium of the medi...

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Main Authors: Hui-Yeng Yeannie Yap, Mariano Jordi Muria-Gonzalez, Boon-Hong Kong, Keith A. Stubbs, Chon-Seng Tan, Szu-Ting Ng, Nget-Hong Tan, Peter S. Solomon, Shin-Yee Fung, Yit-Heng Chooi
Format: Article
Language:English
Published: BioMed Central 2017-06-01
Series:Microbial Cell Factories
Subjects:
Lignosus rhinocerotis
Tiger milk mushroom
Sesquiterpene synthase
Sesquiterpenoid
(+)-Torreyol
α-Cadinol
Online Access:http://link.springer.com/article/10.1186/s12934-017-0713-x

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http://link.springer.com/article/10.1186/s12934-017-0713-x

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