Variants in TPMT, ITPA, ABCC4 And ABCB1 Genes as Predictors of 6-Mercaptopurine Induced Toxicity in Children with Acute Lymphoblastic Leukemia

Variants in TPMT, ITPA, ABCC4 And ABCB1 Genes as Predictors of 6-Mercaptopurine Induced Toxicity in Children with Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia is the most common childhood malignancy. Optimal use of anti leukemic drugs has led to less toxicity and adverse reactions, and a higher survival rate. Thiopurine drugs, including 6-mercaptopurine, are mostly used as antileukemic medications in the maintenance phase of t...

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Bibliographic Details
Main Authors: Milosevic Goran, Kotur Nikola, Krstovski Nada, Lazic Jelena, Zukic Branka, Stankovic Biljana, Janic Dragana, Katsila Theodora, Patrinos George P., Pavlovic Sonja, Dokmanovic Lidija
Format: Article
Language:English
Published: Sciendo 2018-07-01
Series:Journal of Medical Biochemistry
Subjects:
childhood acute lymphoblastic leukemia (ALL)
6-mercaptopurine (6-MP)
TPMT
ITPA
ABCC4
ABCB1
Online Access:http://www.degruyter.com/view/j/jomb.2018.37.issue-3/jomb-2017-0060/jomb-2017-0060.xml?format=INT

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http://www.degruyter.com/view/j/jomb.2018.37.issue-3/jomb-2017-0060/jomb-2017-0060.xml?format=INT

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