Zoledronic acid exacerbates inflammation through M1 macrophage polarization

Zoledronic acid exacerbates inflammation through M1 macrophage polarization

Abstract Background Zoledronic acid (Zol), one of the bisphosphonates, is frequently utilized for the treatment of osteoporosis and bone metastasis. However, the onset of medication-related osteonecrosis of the jaw (MRONJ) following dental treatments has become a serious issue. We reported previousl...

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Bibliographic Details
Main Authors: Junya Kaneko, Toshinori Okinaga, Hisako Hikiji, Wataru Ariyoshi, Daigo Yoshiga, Manabu Habu, Kazuhiro Tominaga, Tatsuji Nishihara
Format: Article
Language:English
Published: BioMed Central 2018-06-01
Series:Inflammation and Regeneration
Subjects:
Zoledronic acid
Macrophage polarization
Inflammation
Online Access:http://link.springer.com/article/10.1186/s41232-018-0074-9

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