High density lipoprotein modulates osteocalcin expression in circulating monocytes: a potential protective mechanism for cardiovascular disease in type 1 diabetes

High density lipoprotein modulates osteocalcin expression in circulating monocytes: a potential protective mechanism for cardiovascular disease in type 1 diabetes

Abstract Background Cardiovascular disease (CVD) is a major cause of mortality in type 1 diabetes (T1D). A pro-calcific drift of circulating monocytes has been linked to vascular calcification and is marked by the surface expression of osteocalcin (OCN). We studied OCN+ monocytes in a unique populat...

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Bibliographic Details
Main Authors: Ernesto Maddaloni, Yu Xia, Kyoungmin Park, Stephanie D’Eon, Liane J. Tinsley, Ronald St-Louis, Mogher Khamaisi, Qian Li, George L. King, Hillary A. Keenan
Format: Article
Language:English
Published: BioMed Central 2017-09-01
Series:Cardiovascular Diabetology
Subjects:
Osteocalcin
Type 1 diabetes
Cardiovascular disease
HDL
Monocytes
Calcifying monocytes
Online Access:http://link.springer.com/article/10.1186/s12933-017-0599-2

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http://link.springer.com/article/10.1186/s12933-017-0599-2

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