The osteoprogenitor-specific loss of ephrinB1 results in an osteoporotic phenotype affecting the balance between bone formation and resorption

The osteoprogenitor-specific loss of ephrinB1 results in an osteoporotic phenotype affecting the balance between bone formation and resorption

Abstract The present study investigated the effects of conditional deletion of ephrinB1 in osteoprogenitor cells driven by the Osterix (Osx) promoter, on skeletal integrity in a murine model of ovariectomy-induced (OVX) osteoporosis. Histomorphometric and μCT analyses revealed that loss of ephrinB1...

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Bibliographic Details
Main Authors: Agnieszka Arthur, Thao M. Nguyen, Sharon Paton, Ana Klisuric, Andrew C. W. Zannettino, Stan Gronthos
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Scientific Reports
Online Access:http://link.springer.com/article/10.1038/s41598-018-31190-2

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http://link.springer.com/article/10.1038/s41598-018-31190-2

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