Reintroducing testosterone in the db/db mouse partially restores normal glucose metabolism and insulin resistance in a leptin-independent manner

Reintroducing testosterone in the db/db mouse partially restores normal glucose metabolism and insulin resistance in a leptin-independent manner

Abstract Background Testosterone signals through the androgen receptor (AR) and AR knockout mice develop obesity, suggesting a functional association between AR and leptin signaling. Furthermore, physiological blood concentrations of testosterone have been found to inhibit the development of arterio...

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Bibliographic Details
Main Authors: Koichi Yabiku, Keiko Nakamoto, Akihiro Tokushige
Format: Article
Language:English
Published: BioMed Central 2018-06-01
Series:BMC Endocrine Disorders
Subjects:
Testosterone replacement
Leptin signal knockout
Aromatization
Impaired glucose tolerance
Fatty liver
Online Access:http://link.springer.com/article/10.1186/s12902-018-0266-y

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http://link.springer.com/article/10.1186/s12902-018-0266-y

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