The N- and C-terminal carbohydrate recognition domains of Haemonchus contortus galectin bind to distinct receptors of goat PBMC and contribute differently to its immunomodulatory functions in host-parasite interactions

The N- and C-terminal carbohydrate recognition domains of Haemonchus contortus galectin bind to distinct receptors of goat PBMC and contribute differently to its immunomodulatory functions in host-parasite interactions

Abstract Background Hco-gal-m is a tandem-repeat galectin isolated from the adult worm of Haemonchus contortus. A growing body of studies have demonstrated that Hco-gal-m could exert its immunomodulatory effects on host peripheral blood mononuclear cells (PBMC) to facilitate the immune evasion. Our...

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Bibliographic Details
Main Authors: MingMin Lu, XiaoWei Tian, XinChao Yang, Cheng Yuan, Muhammad Ehsan, XinChao Liu, RuoFeng Yan, LiXin Xu, XiaoKai Song, XiangRui Li
Format: Article
Language:English
Published: BioMed Central 2017-09-01
Series:Parasites & Vectors
Subjects:
Galectin
Haemonchus contortus
Carbohydrate recognition domain
PBMC
Receptor
Immunomodulatory
Online Access:http://link.springer.com/article/10.1186/s13071-017-2353-8

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http://link.springer.com/article/10.1186/s13071-017-2353-8

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