Pyrrolizine-5-carboxamides: Exploring the impact of various substituents on anti-inflammatory and anticancer activities

Towards optimization of the pyrrolizine-5-carboxamide scaffold, a novel series of six derivatives (4a-c and 5a-c) was prepared and evaluated for their anti-inflammatory, analgesic and anticancer activities. The (EZ)-7-cyano-6-((4-hydroxybenzylidene)amino)-N-(p-tolyl)-2,3-dihydro-1H-pyrrolizine-5-car...

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Bibliographic Details
Main Authors: Gouda Ahmed M., Abdelazeem Ahmed H., Abdalla Ashraf N., Ahmed Muhammad
Format: Article
Language:English
Published: Sciendo 2018-09-01
Series:Acta Pharmaceutica
Subjects:
Online Access:http://www.degruyter.com/view/j/acph.2018.68.issue-3/acph-2018-0026/acph-2018-0026.xml?format=INT