Strong epistatic and additive effects of linked candidate SNPs for Drosophila pigmentation have implications for analysis of genome-wide association studies results

Strong epistatic and additive effects of linked candidate SNPs for Drosophila pigmentation have implications for analysis of genome-wide association studies results

Abstract Background The mapping resolution of genome-wide association studies (GWAS) is limited by historic recombination events and effects are often assigned to haplotype blocks rather than individual SNPs. It is not clear how many of the SNPs in the block, and which ones, are causative. Drosophil...

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Bibliographic Details
Main Authors: Jean-Michel Gibert, Jorge Blanco, Marlies Dolezal, Viola Nolte, Frédérique Peronnet, Christian Schlötterer
Format: Article
Language:English
Published: BioMed Central 2017-07-01
Series:Genome Biology
Subjects:
Genome-wide associations studies (GWAS)
Genetic architecture
Additivity
Epistasis
Pigmentation
Drosophila
Online Access:http://link.springer.com/article/10.1186/s13059-017-1262-7

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http://link.springer.com/article/10.1186/s13059-017-1262-7

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