Prediction of Gestational Diabetes Mellitus and Pre-diabetes 5 Years Postpartum using 75 g Oral Glucose Tolerance Test at 14–16 Weeks’ Gestation

Abstract Early detection and treatment of women at risk for gestational diabetes mellitus (GDM) could improve perinatal and long-term outcomes in GDM women and their offspring. We explored if a 75 g oral glucose tolerance test (OGTT) at 14–16 weeks of gestation could identify women who will (1) deve...

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Main Authors:	Tove Lekva, Kristin Godang, Annika E. Michelsen, Elisabeth Qvigstad, Kjersti Ringvoll Normann, Errol R. Norwitz, Pål Aukrust, Tore Henriksen, Jens Bollerslev, Marie Cecilie Paasche Roland, Thor Ueland
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-09-01
Series:	Scientific Reports
Online Access:	http://link.springer.com/article/10.1038/s41598-018-31614-z

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spelling	doaj-art-18a206ce67c44075a7298d470cfbb6632018-09-09T12:16:16ZengNature Publishing GroupScientific Reports2045-23222018-09-01811910.1038/s41598-018-31614-zPrediction of Gestational Diabetes Mellitus and Pre-diabetes 5 Years Postpartum using 75 g Oral Glucose Tolerance Test at 14–16 Weeks’ GestationTove Lekva0Kristin Godang1Annika E. Michelsen2Elisabeth Qvigstad3Kjersti Ringvoll Normann4Errol R. Norwitz5Pål Aukrust6Tore Henriksen7Jens Bollerslev8Marie Cecilie Paasche Roland9Thor Ueland10Research Institute of Internal Medicine, Oslo University Hospital, RikshospitaletSection of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital, RikshospitaletResearch Institute of Internal Medicine, Oslo University Hospital, RikshospitaletDepartment of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, AkerResearch Institute of Internal Medicine, Oslo University Hospital, RikshospitaletMother Infant Research Institute, Tufts Medical CenterResearch Institute of Internal Medicine, Oslo University Hospital, RikshospitaletFaculty of Medicine, University of OsloSection of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital, RikshospitaletNational Advisory Unit for Womens Health, Oslo University Hospital, RikshospitaletResearch Institute of Internal Medicine, Oslo University Hospital, RikshospitaletAbstract Early detection and treatment of women at risk for gestational diabetes mellitus (GDM) could improve perinatal and long-term outcomes in GDM women and their offspring. We explored if a 75 g oral glucose tolerance test (OGTT) at 14–16 weeks of gestation could identify women who will (1) develop GDM or give birth to large-for-gestational-age (LGA) babies in 1031 pregnant women from the STORK study using different diagnostic criteria (WHO1999, IADPSG2010, WHO2013, NORWAY2017) and (2) develop pre-diabetes 5 years postpartum focusing on first trimester β-cell function in a separate study of 300 women from the STORK cohort. The sensitivity of the 14–16 week OGTT to identify women who would develop GDM or have LGA babies was low, and we could not identify alternative cut-offs to exclude women not at risk or identify women that could benefit from early intervention. First trimester β-cell function was a stronger determinant than third trimester β-cell function of predicting maternal pre-diabetes. In conclusion, in our normal low-risk population, the 75 g OGTT at 14–16 weeks is insufficient to identify candidates for early treatment of GDM or identify women not likely to develop GDM or have LGA babies. First trimester β-cell function may predict pre-diabetes 5 years postpartum.http://link.springer.com/article/10.1038/s41598-018-31614-z
institution	Open Data Bank
collection	Open Access Journals
building	Directory of Open Access Journals
language	English
format	Article
author	Tove Lekva Kristin Godang Annika E. Michelsen Elisabeth Qvigstad Kjersti Ringvoll Normann Errol R. Norwitz Pål Aukrust Tore Henriksen Jens Bollerslev Marie Cecilie Paasche Roland Thor Ueland
spellingShingle	Tove Lekva Kristin Godang Annika E. Michelsen Elisabeth Qvigstad Kjersti Ringvoll Normann Errol R. Norwitz Pål Aukrust Tore Henriksen Jens Bollerslev Marie Cecilie Paasche Roland Thor Ueland Prediction of Gestational Diabetes Mellitus and Pre-diabetes 5 Years Postpartum using 75 g Oral Glucose Tolerance Test at 14–16 Weeks’ Gestation Scientific Reports
author_facet	Tove Lekva Kristin Godang Annika E. Michelsen Elisabeth Qvigstad Kjersti Ringvoll Normann Errol R. Norwitz Pål Aukrust Tore Henriksen Jens Bollerslev Marie Cecilie Paasche Roland Thor Ueland
author_sort	Tove Lekva
title	Prediction of Gestational Diabetes Mellitus and Pre-diabetes 5 Years Postpartum using 75 g Oral Glucose Tolerance Test at 14–16 Weeks’ Gestation
title_short	Prediction of Gestational Diabetes Mellitus and Pre-diabetes 5 Years Postpartum using 75 g Oral Glucose Tolerance Test at 14–16 Weeks’ Gestation
title_full	Prediction of Gestational Diabetes Mellitus and Pre-diabetes 5 Years Postpartum using 75 g Oral Glucose Tolerance Test at 14–16 Weeks’ Gestation
title_fullStr	Prediction of Gestational Diabetes Mellitus and Pre-diabetes 5 Years Postpartum using 75 g Oral Glucose Tolerance Test at 14–16 Weeks’ Gestation
title_full_unstemmed	Prediction of Gestational Diabetes Mellitus and Pre-diabetes 5 Years Postpartum using 75 g Oral Glucose Tolerance Test at 14–16 Weeks’ Gestation
title_sort	prediction of gestational diabetes mellitus and pre-diabetes 5 years postpartum using 75 g oral glucose tolerance test at 14–16 weeks’ gestation
publisher	Nature Publishing Group
series	Scientific Reports
issn	2045-2322
publishDate	2018-09-01
description	Abstract Early detection and treatment of women at risk for gestational diabetes mellitus (GDM) could improve perinatal and long-term outcomes in GDM women and their offspring. We explored if a 75 g oral glucose tolerance test (OGTT) at 14–16 weeks of gestation could identify women who will (1) develop GDM or give birth to large-for-gestational-age (LGA) babies in 1031 pregnant women from the STORK study using different diagnostic criteria (WHO1999, IADPSG2010, WHO2013, NORWAY2017) and (2) develop pre-diabetes 5 years postpartum focusing on first trimester β-cell function in a separate study of 300 women from the STORK cohort. The sensitivity of the 14–16 week OGTT to identify women who would develop GDM or have LGA babies was low, and we could not identify alternative cut-offs to exclude women not at risk or identify women that could benefit from early intervention. First trimester β-cell function was a stronger determinant than third trimester β-cell function of predicting maternal pre-diabetes. In conclusion, in our normal low-risk population, the 75 g OGTT at 14–16 weeks is insufficient to identify candidates for early treatment of GDM or identify women not likely to develop GDM or have LGA babies. First trimester β-cell function may predict pre-diabetes 5 years postpartum.
url	http://link.springer.com/article/10.1038/s41598-018-31614-z
_version_	1612608166118293504

Prediction of Gestational Diabetes Mellitus and Pre-diabetes 5 Years Postpartum using 75 g Oral Glucose Tolerance Test at 14–16 Weeks’ Gestation

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