Evaluation of dosing strategy for pembrolizumab for oncology indications

Evaluation of dosing strategy for pembrolizumab for oncology indications

Abstract Background Traditionally, most monoclonal antibodies (mAbs) have been dosed based on body weight because of perceived contribution of body size in pharmacokinetic variability. The same approach was used in the initial pembrolizumab studies; however, following availability of PK data, the ne...

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Bibliographic Details
Main Authors: Tomoko Freshwater, Anna Kondic, Malidi Ahamadi, Claire H. Li, Rik de Greef, Dinesh de Alwis, Julie A. Stone
Format: Article
Language:English
Published: BioMed Central 2017-05-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Pembrolizumab
Fixed dose
Flat dose
Dosing strategy
Clinical dose
Exposure-response analysis
Online Access:http://link.springer.com/article/10.1186/s40425-017-0242-5

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http://link.springer.com/article/10.1186/s40425-017-0242-5

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