Advances in Studies Related to Interleukin-12 Family and Infectious Diseases
Interleukin (IL)-12 family is a group of cytokines composed of heterogeneous molecules and whose members include IL-12, IL-23, IL-27, and IL-35. IL-12 family bridges natural and adaptive immune responses and especially plays a significant role in classical adaptive immune process participated by TH1...
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doaj-art-109d85a1a77d4235b2092ee406fb41c62018-09-02T16:05:59ZengSciendoInfection International2544-03492015-06-0142353910.1515/ii-2017-0103ii-2017-0103Advances in Studies Related to Interleukin-12 Family and Infectious DiseasesLi Bo0Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, TianjinChinaInterleukin (IL)-12 family is a group of cytokines composed of heterogeneous molecules and whose members include IL-12, IL-23, IL-27, and IL-35. IL-12 family bridges natural and adaptive immune responses and especially plays a significant role in classical adaptive immune process participated by TH1, TH17, and Treg cells. Members of IL-12 family participate in adaptive immune responses via the Janus kinase-signal transducers and activators of transcription signaling pathway by sharing some subunits and receptors. IL-12 features an extremely complex regulatory network. During resistance of microbial infection, IL-12 and IL-23 mainly show inflammatory effects, whereas IL-27 and IL-35 commonly show antiinflammatory effects. This study reviews advances in studies related to IL-12 family members and infectious diseases and provides references to further reveal functions of IL-12 family members in occurrence and development of infectious diseases.http://www.degruyter.com/view/j/ii.2015.4.issue-2/ii-2017-0103/ii-2017-0103.xml?format=INTInterleukinIL-12IL-23IL-35Infectious diseases |
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Li Bo Advances in Studies Related to Interleukin-12 Family and Infectious Diseases Infection International Interleukin IL-12 IL-23 IL-35 Infectious diseases |
author_facet |
Li Bo |
author_sort |
Li Bo |
title |
Advances in Studies Related to Interleukin-12 Family and Infectious Diseases |
title_short |
Advances in Studies Related to Interleukin-12 Family and Infectious Diseases |
title_full |
Advances in Studies Related to Interleukin-12 Family and Infectious Diseases |
title_fullStr |
Advances in Studies Related to Interleukin-12 Family and Infectious Diseases |
title_full_unstemmed |
Advances in Studies Related to Interleukin-12 Family and Infectious Diseases |
title_sort |
advances in studies related to interleukin-12 family and infectious diseases |
publisher |
Sciendo |
series |
Infection International |
issn |
2544-0349 |
publishDate |
2015-06-01 |
description |
Interleukin (IL)-12 family is a group of cytokines composed of heterogeneous molecules and whose members include IL-12, IL-23, IL-27, and IL-35. IL-12 family bridges natural and adaptive immune responses and especially plays a significant role in classical adaptive immune process participated by TH1, TH17, and Treg cells. Members of IL-12 family participate in adaptive immune responses via the Janus kinase-signal transducers and activators of transcription signaling pathway by sharing some subunits and receptors. IL-12 features an extremely complex regulatory network. During resistance of microbial infection, IL-12 and IL-23 mainly show inflammatory effects, whereas IL-27 and IL-35 commonly show antiinflammatory effects. This study reviews advances in studies related to IL-12 family members and infectious diseases and provides references to further reveal functions of IL-12 family members in occurrence and development of infectious diseases. |
topic |
Interleukin IL-12 IL-23 IL-35 Infectious diseases |
url |
http://www.degruyter.com/view/j/ii.2015.4.issue-2/ii-2017-0103/ii-2017-0103.xml?format=INT |
_version_ |
1612635685732220928 |