Advances in Studies Related to Interleukin-12 Family and Infectious Diseases

Interleukin (IL)-12 family is a group of cytokines composed of heterogeneous molecules and whose members include IL-12, IL-23, IL-27, and IL-35. IL-12 family bridges natural and adaptive immune responses and especially plays a significant role in classical adaptive immune process participated by TH1...

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Main Author:	Li Bo
Format:	Article
Language:	English
Published:	Sciendo 2015-06-01
Series:	Infection International
Subjects:	Interleukin IL-12 IL-23 IL-35 Infectious diseases
Online Access:	http://www.degruyter.com/view/j/ii.2015.4.issue-2/ii-2017-0103/ii-2017-0103.xml?format=INT

id	doaj-art-109d85a1a77d4235b2092ee406fb41c6
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spelling	doaj-art-109d85a1a77d4235b2092ee406fb41c62018-09-02T16:05:59ZengSciendoInfection International2544-03492015-06-0142353910.1515/ii-2017-0103ii-2017-0103Advances in Studies Related to Interleukin-12 Family and Infectious DiseasesLi Bo0Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, TianjinChinaInterleukin (IL)-12 family is a group of cytokines composed of heterogeneous molecules and whose members include IL-12, IL-23, IL-27, and IL-35. IL-12 family bridges natural and adaptive immune responses and especially plays a significant role in classical adaptive immune process participated by TH1, TH17, and Treg cells. Members of IL-12 family participate in adaptive immune responses via the Janus kinase-signal transducers and activators of transcription signaling pathway by sharing some subunits and receptors. IL-12 features an extremely complex regulatory network. During resistance of microbial infection, IL-12 and IL-23 mainly show inflammatory effects, whereas IL-27 and IL-35 commonly show antiinflammatory effects. This study reviews advances in studies related to IL-12 family members and infectious diseases and provides references to further reveal functions of IL-12 family members in occurrence and development of infectious diseases.http://www.degruyter.com/view/j/ii.2015.4.issue-2/ii-2017-0103/ii-2017-0103.xml?format=INTInterleukinIL-12IL-23IL-35Infectious diseases
institution	Open Data Bank
collection	Open Access Journals
building	Directory of Open Access Journals
language	English
format	Article
author	Li Bo
spellingShingle	Li Bo Advances in Studies Related to Interleukin-12 Family and Infectious Diseases Infection International Interleukin IL-12 IL-23 IL-35 Infectious diseases
author_facet	Li Bo
author_sort	Li Bo
title	Advances in Studies Related to Interleukin-12 Family and Infectious Diseases
title_short	Advances in Studies Related to Interleukin-12 Family and Infectious Diseases
title_full	Advances in Studies Related to Interleukin-12 Family and Infectious Diseases
title_fullStr	Advances in Studies Related to Interleukin-12 Family and Infectious Diseases
title_full_unstemmed	Advances in Studies Related to Interleukin-12 Family and Infectious Diseases
title_sort	advances in studies related to interleukin-12 family and infectious diseases
publisher	Sciendo
series	Infection International
issn	2544-0349
publishDate	2015-06-01
description	Interleukin (IL)-12 family is a group of cytokines composed of heterogeneous molecules and whose members include IL-12, IL-23, IL-27, and IL-35. IL-12 family bridges natural and adaptive immune responses and especially plays a significant role in classical adaptive immune process participated by TH1, TH17, and Treg cells. Members of IL-12 family participate in adaptive immune responses via the Janus kinase-signal transducers and activators of transcription signaling pathway by sharing some subunits and receptors. IL-12 features an extremely complex regulatory network. During resistance of microbial infection, IL-12 and IL-23 mainly show inflammatory effects, whereas IL-27 and IL-35 commonly show antiinflammatory effects. This study reviews advances in studies related to IL-12 family members and infectious diseases and provides references to further reveal functions of IL-12 family members in occurrence and development of infectious diseases.
topic	Interleukin IL-12 IL-23 IL-35 Infectious diseases
url	http://www.degruyter.com/view/j/ii.2015.4.issue-2/ii-2017-0103/ii-2017-0103.xml?format=INT
_version_	1612635685732220928

Advances in Studies Related to Interleukin-12 Family and Infectious Diseases

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