Advances in Studies Related to Interleukin-12 Family and Infectious Diseases

Interleukin (IL)-12 family is a group of cytokines composed of heterogeneous molecules and whose members include IL-12, IL-23, IL-27, and IL-35. IL-12 family bridges natural and adaptive immune responses and especially plays a significant role in classical adaptive immune process participated by TH1...

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Main Author: Li Bo
Format: Article
Language:English
Published: Sciendo 2015-06-01
Series:Infection International
Subjects:
Online Access:http://www.degruyter.com/view/j/ii.2015.4.issue-2/ii-2017-0103/ii-2017-0103.xml?format=INT
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spelling doaj-art-109d85a1a77d4235b2092ee406fb41c62018-09-02T16:05:59ZengSciendoInfection International2544-03492015-06-0142353910.1515/ii-2017-0103ii-2017-0103Advances in Studies Related to Interleukin-12 Family and Infectious DiseasesLi Bo0Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, TianjinChinaInterleukin (IL)-12 family is a group of cytokines composed of heterogeneous molecules and whose members include IL-12, IL-23, IL-27, and IL-35. IL-12 family bridges natural and adaptive immune responses and especially plays a significant role in classical adaptive immune process participated by TH1, TH17, and Treg cells. Members of IL-12 family participate in adaptive immune responses via the Janus kinase-signal transducers and activators of transcription signaling pathway by sharing some subunits and receptors. IL-12 features an extremely complex regulatory network. During resistance of microbial infection, IL-12 and IL-23 mainly show inflammatory effects, whereas IL-27 and IL-35 commonly show antiinflammatory effects. This study reviews advances in studies related to IL-12 family members and infectious diseases and provides references to further reveal functions of IL-12 family members in occurrence and development of infectious diseases.http://www.degruyter.com/view/j/ii.2015.4.issue-2/ii-2017-0103/ii-2017-0103.xml?format=INTInterleukinIL-12IL-23IL-35Infectious diseases
institution Open Data Bank
collection Open Access Journals
building Directory of Open Access Journals
language English
format Article
author Li Bo
spellingShingle Li Bo
Advances in Studies Related to Interleukin-12 Family and Infectious Diseases
Infection International
Interleukin
IL-12
IL-23
IL-35
Infectious diseases
author_facet Li Bo
author_sort Li Bo
title Advances in Studies Related to Interleukin-12 Family and Infectious Diseases
title_short Advances in Studies Related to Interleukin-12 Family and Infectious Diseases
title_full Advances in Studies Related to Interleukin-12 Family and Infectious Diseases
title_fullStr Advances in Studies Related to Interleukin-12 Family and Infectious Diseases
title_full_unstemmed Advances in Studies Related to Interleukin-12 Family and Infectious Diseases
title_sort advances in studies related to interleukin-12 family and infectious diseases
publisher Sciendo
series Infection International
issn 2544-0349
publishDate 2015-06-01
description Interleukin (IL)-12 family is a group of cytokines composed of heterogeneous molecules and whose members include IL-12, IL-23, IL-27, and IL-35. IL-12 family bridges natural and adaptive immune responses and especially plays a significant role in classical adaptive immune process participated by TH1, TH17, and Treg cells. Members of IL-12 family participate in adaptive immune responses via the Janus kinase-signal transducers and activators of transcription signaling pathway by sharing some subunits and receptors. IL-12 features an extremely complex regulatory network. During resistance of microbial infection, IL-12 and IL-23 mainly show inflammatory effects, whereas IL-27 and IL-35 commonly show antiinflammatory effects. This study reviews advances in studies related to IL-12 family members and infectious diseases and provides references to further reveal functions of IL-12 family members in occurrence and development of infectious diseases.
topic Interleukin
IL-12
IL-23
IL-35
Infectious diseases
url http://www.degruyter.com/view/j/ii.2015.4.issue-2/ii-2017-0103/ii-2017-0103.xml?format=INT
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