Mapping mitochondrial heteroplasmy in a Leydig tumor by laser capture micro-dissection and cycling temperature capillary electrophoresis

Mapping mitochondrial heteroplasmy in a Leydig tumor by laser capture micro-dissection and cycling temperature capillary electrophoresis

Abstract Background The growth of tumor cells is accompanied by mutations in nuclear and mitochondrial genomes creating marked genetic heterogeneity. Tumors also contain non-tumor cells of various origins. An observed somatic mitochondrial mutation would have occurred in a founding cell and spread t...

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Bibliographic Details
Main Authors: Paulo Refinetti, Christian Arstad, William G. Thilly, Stephan Morgenthaler, Per Olaf Ekstrøm
Format: Article
Language:English
Published: BioMed Central 2017-04-01
Series:BMC Clinical Pathology
Subjects:
Capillary electrophoresis
Mitochondrial mutations
Heteroplasmy
Homoplasmy
LCM
Tumor heterogeneity
Online Access:http://link.springer.com/article/10.1186/s12907-017-0042-3

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http://link.springer.com/article/10.1186/s12907-017-0042-3

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