Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China

Abstract Background Genetic variations in key DNA repair genes may influence DNA repair capacity, DNA damage and breast carcinogenesis. The current study aimed to estimate the association of APEX1 and OGG1 polymorphisms with the risk of breast cancer development. Methods A total of 518 patients with...

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Main Authors:	Tao Wang, Haitao Wang, Suisheng Yang, Hongyun Guo, Binming Zhang, Huan Guo, Lan Wang, Gongjian Zhu, Yongdong Zhang, Haihong Zhou, Xiuli Zhang, Haining Li, Haixiang Su
Format:	Article
Language:	English
Published:	BioMed Central 2018-05-01
Series:	BMC Medical Genetics
Subjects:	APEX1 OGG1 Polymorphisms Haplotype Breast cancer
Online Access:	http://link.springer.com/article/10.1186/s12881-018-0578-9

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spelling	doaj-art-0885abc185a240da921e831eaad7a23f2018-08-20T18:59:56ZengBioMed CentralBMC Medical Genetics1471-23502018-05-011911910.1186/s12881-018-0578-9Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of ChinaTao Wang0Haitao Wang1Suisheng Yang2Hongyun Guo3Binming Zhang4Huan Guo5Lan Wang6Gongjian Zhu7Yongdong Zhang8Haihong Zhou9Xiuli Zhang10Haining Li11Haixiang Su12Research Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchDepartment of Breast Surgery, Gansu Provincial Cancer HospitalResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchDepartment of Breast Surgery, Gansu Provincial Cancer HospitalResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchAbstract Background Genetic variations in key DNA repair genes may influence DNA repair capacity, DNA damage and breast carcinogenesis. The current study aimed to estimate the association of APEX1 and OGG1 polymorphisms with the risk of breast cancer development. Methods A total of 518 patients with histopathologically confirmed breast cancer and 921 region- and age-matched cancer-free controls were genotyped for the APEX1 polymorphisms rs3136817 and rs1130409 and the OGG1 polymorphisms rs1052133 and rs2072668 using a QuantStudio™ 12 K Flex Real-Time PCR System. Results The rs3136817 heterozygous TC genotype along with the rs3136817 dominant model (TC + CC) was strongly associated with breast cancer susceptibility (odds ratio [OR] = 0.670, 95% confidence interval [95% CI]: 0.513 - 0.873, P = 0.003; OR = 0.682, 95% CI: 0.526 - 0.883, P = 0.004, respectively). No significant associations were observed among rs1130409, rs1052133, rs2072668 and breast cancer risk. Furthermore, an allele combination analysis revealed that APEX1 haplotypes containing C-T (alleles rs3136817 and rs1130409) conferred a significantly lower risk (corrected P < 0.001). Conclusion This research is the latest report showing that an APEX1 rs3136817 heterozygous genotype may have a positive influence on DNA repair capacity in patients with breast cancer and thus may have a potential protective effect for Chinese Han women.http://link.springer.com/article/10.1186/s12881-018-0578-9APEX1OGG1PolymorphismsHaplotypeBreast cancer
institution	Open Data Bank
collection	Open Access Journals
building	Directory of Open Access Journals
language	English
format	Article
author	Tao Wang Haitao Wang Suisheng Yang Hongyun Guo Binming Zhang Huan Guo Lan Wang Gongjian Zhu Yongdong Zhang Haihong Zhou Xiuli Zhang Haining Li Haixiang Su
spellingShingle	Tao Wang Haitao Wang Suisheng Yang Hongyun Guo Binming Zhang Huan Guo Lan Wang Gongjian Zhu Yongdong Zhang Haihong Zhou Xiuli Zhang Haining Li Haixiang Su Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China BMC Medical Genetics APEX1 OGG1 Polymorphisms Haplotype Breast cancer
author_facet	Tao Wang Haitao Wang Suisheng Yang Hongyun Guo Binming Zhang Huan Guo Lan Wang Gongjian Zhu Yongdong Zhang Haihong Zhou Xiuli Zhang Haining Li Haixiang Su
author_sort	Tao Wang
title	Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China
title_short	Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China
title_full	Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China
title_fullStr	Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China
title_full_unstemmed	Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China
title_sort	association of apex1 and ogg1 gene polymorphisms with breast cancer risk among han women in the gansu province of china
publisher	BioMed Central
series	BMC Medical Genetics
issn	1471-2350
publishDate	2018-05-01
description	Abstract Background Genetic variations in key DNA repair genes may influence DNA repair capacity, DNA damage and breast carcinogenesis. The current study aimed to estimate the association of APEX1 and OGG1 polymorphisms with the risk of breast cancer development. Methods A total of 518 patients with histopathologically confirmed breast cancer and 921 region- and age-matched cancer-free controls were genotyped for the APEX1 polymorphisms rs3136817 and rs1130409 and the OGG1 polymorphisms rs1052133 and rs2072668 using a QuantStudio™ 12 K Flex Real-Time PCR System. Results The rs3136817 heterozygous TC genotype along with the rs3136817 dominant model (TC + CC) was strongly associated with breast cancer susceptibility (odds ratio [OR] = 0.670, 95% confidence interval [95% CI]: 0.513 - 0.873, P = 0.003; OR = 0.682, 95% CI: 0.526 - 0.883, P = 0.004, respectively). No significant associations were observed among rs1130409, rs1052133, rs2072668 and breast cancer risk. Furthermore, an allele combination analysis revealed that APEX1 haplotypes containing C-T (alleles rs3136817 and rs1130409) conferred a significantly lower risk (corrected P < 0.001). Conclusion This research is the latest report showing that an APEX1 rs3136817 heterozygous genotype may have a positive influence on DNA repair capacity in patients with breast cancer and thus may have a potential protective effect for Chinese Han women.
topic	APEX1 OGG1 Polymorphisms Haplotype Breast cancer
url	http://link.springer.com/article/10.1186/s12881-018-0578-9
_version_	1612683172568367104

Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China

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