Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China

Abstract Background Genetic variations in key DNA repair genes may influence DNA repair capacity, DNA damage and breast carcinogenesis. The current study aimed to estimate the association of APEX1 and OGG1 polymorphisms with the risk of breast cancer development. Methods A total of 518 patients with...

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Main Authors: Tao Wang, Haitao Wang, Suisheng Yang, Hongyun Guo, Binming Zhang, Huan Guo, Lan Wang, Gongjian Zhu, Yongdong Zhang, Haihong Zhou, Xiuli Zhang, Haining Li, Haixiang Su
Format: Article
Language:English
Published: BioMed Central 2018-05-01
Series:BMC Medical Genetics
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12881-018-0578-9
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spelling doaj-art-0885abc185a240da921e831eaad7a23f2018-08-20T18:59:56ZengBioMed CentralBMC Medical Genetics1471-23502018-05-011911910.1186/s12881-018-0578-9Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of ChinaTao Wang0Haitao Wang1Suisheng Yang2Hongyun Guo3Binming Zhang4Huan Guo5Lan Wang6Gongjian Zhu7Yongdong Zhang8Haihong Zhou9Xiuli Zhang10Haining Li11Haixiang Su12Research Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchDepartment of Breast Surgery, Gansu Provincial Cancer HospitalResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchDepartment of Breast Surgery, Gansu Provincial Cancer HospitalResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchResearch Center of Translational Medicine, Gansu Provincial Academic Institute for Medical ResearchAbstract Background Genetic variations in key DNA repair genes may influence DNA repair capacity, DNA damage and breast carcinogenesis. The current study aimed to estimate the association of APEX1 and OGG1 polymorphisms with the risk of breast cancer development. Methods A total of 518 patients with histopathologically confirmed breast cancer and 921 region- and age-matched cancer-free controls were genotyped for the APEX1 polymorphisms rs3136817 and rs1130409 and the OGG1 polymorphisms rs1052133 and rs2072668 using a QuantStudio™ 12 K Flex Real-Time PCR System. Results The rs3136817 heterozygous TC genotype along with the rs3136817 dominant model (TC + CC) was strongly associated with breast cancer susceptibility (odds ratio [OR] = 0.670, 95% confidence interval [95% CI]: 0.513 - 0.873, P = 0.003; OR = 0.682, 95% CI: 0.526 - 0.883, P = 0.004, respectively). No significant associations were observed among rs1130409, rs1052133, rs2072668 and breast cancer risk. Furthermore, an allele combination analysis revealed that APEX1 haplotypes containing C-T (alleles rs3136817 and rs1130409) conferred a significantly lower risk (corrected P < 0.001). Conclusion This research is the latest report showing that an APEX1 rs3136817 heterozygous genotype may have a positive influence on DNA repair capacity in patients with breast cancer and thus may have a potential protective effect for Chinese Han women.http://link.springer.com/article/10.1186/s12881-018-0578-9APEX1OGG1PolymorphismsHaplotypeBreast cancer
institution Open Data Bank
collection Open Access Journals
building Directory of Open Access Journals
language English
format Article
author Tao Wang
Haitao Wang
Suisheng Yang
Hongyun Guo
Binming Zhang
Huan Guo
Lan Wang
Gongjian Zhu
Yongdong Zhang
Haihong Zhou
Xiuli Zhang
Haining Li
Haixiang Su
spellingShingle Tao Wang
Haitao Wang
Suisheng Yang
Hongyun Guo
Binming Zhang
Huan Guo
Lan Wang
Gongjian Zhu
Yongdong Zhang
Haihong Zhou
Xiuli Zhang
Haining Li
Haixiang Su
Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China
BMC Medical Genetics
APEX1
OGG1
Polymorphisms
Haplotype
Breast cancer
author_facet Tao Wang
Haitao Wang
Suisheng Yang
Hongyun Guo
Binming Zhang
Huan Guo
Lan Wang
Gongjian Zhu
Yongdong Zhang
Haihong Zhou
Xiuli Zhang
Haining Li
Haixiang Su
author_sort Tao Wang
title Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China
title_short Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China
title_full Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China
title_fullStr Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China
title_full_unstemmed Association of APEX1 and OGG1 gene polymorphisms with breast cancer risk among Han women in the Gansu Province of China
title_sort association of apex1 and ogg1 gene polymorphisms with breast cancer risk among han women in the gansu province of china
publisher BioMed Central
series BMC Medical Genetics
issn 1471-2350
publishDate 2018-05-01
description Abstract Background Genetic variations in key DNA repair genes may influence DNA repair capacity, DNA damage and breast carcinogenesis. The current study aimed to estimate the association of APEX1 and OGG1 polymorphisms with the risk of breast cancer development. Methods A total of 518 patients with histopathologically confirmed breast cancer and 921 region- and age-matched cancer-free controls were genotyped for the APEX1 polymorphisms rs3136817 and rs1130409 and the OGG1 polymorphisms rs1052133 and rs2072668 using a QuantStudio™ 12 K Flex Real-Time PCR System. Results The rs3136817 heterozygous TC genotype along with the rs3136817 dominant model (TC + CC) was strongly associated with breast cancer susceptibility (odds ratio [OR] = 0.670, 95% confidence interval [95% CI]: 0.513 - 0.873, P = 0.003; OR = 0.682, 95% CI: 0.526 - 0.883, P = 0.004, respectively). No significant associations were observed among rs1130409, rs1052133, rs2072668 and breast cancer risk. Furthermore, an allele combination analysis revealed that APEX1 haplotypes containing C-T (alleles rs3136817 and rs1130409) conferred a significantly lower risk (corrected P < 0.001). Conclusion This research is the latest report showing that an APEX1 rs3136817 heterozygous genotype may have a positive influence on DNA repair capacity in patients with breast cancer and thus may have a potential protective effect for Chinese Han women.
topic APEX1
OGG1
Polymorphisms
Haplotype
Breast cancer
url http://link.springer.com/article/10.1186/s12881-018-0578-9
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