Associations between gonadotropins, testosterone and [beta] amyloid in men at risk of Alzheimer’s disease

Testosterone and gonadotropins have been associated with cognitive decline in men and the modulation of β amyloid (Aβ) metabolism. The relatively few studies that have investigated whether changes in one or a combination of these hormones influence Aβ levels have focused primarily on plasma Aβ1–40 a...

Full description

Bibliographic Details
Main Authors:	Verdile, Giuseppe, Laws, S., Henley, D., Ames, D., Bush, A., Ellis, K., Faux, N., Gupta, V., Li, Q., Masters, C., Pike, K., Rowe, C., Szoeke, C., Taddei, K., Villemagne, V., Martins, R.
Format:	Journal Article
Published:	Nature Publishing Group 2014
Online Access:	http://hdl.handle.net/20.500.11937/7789

id	curtin-20.500.11937-7789
recordtype	eprints
spelling	curtin-20.500.11937-77892017-09-13T14:35:41Z Associations between gonadotropins, testosterone and [beta] amyloid in men at risk of Alzheimer’s disease Verdile, Giuseppe Laws, S. Henley, D. Ames, D. Bush, A. Ellis, K. Faux, N. Gupta, V. Li, Q. Masters, C. Pike, K. Rowe, C. Szoeke, C. Taddei, K. Villemagne, V. Martins, R. Testosterone and gonadotropins have been associated with cognitive decline in men and the modulation of β amyloid (Aβ) metabolism. The relatively few studies that have investigated whether changes in one or a combination of these hormones influence Aβ levels have focused primarily on plasma Aβ1–40 and not on the more pathogenic Aβ1–42. Currently, no study has investigated whether these hormones are associated with an increase in brain amyloid deposition, ante mortem. Through the highly characterised Australian imaging, biomarkers and lifestyle study, we have determined the impact of these hormones on plasma Aβ levels and brain amyloid burden (Pittsburgh compound B (PiB) retention). Spearman’s rank correlation and linear regression analysis was carried out across the cohort and within subclassifications. Luteinizing hormone (LH) was the only variable shown, in the total cohort, to have a significant impact on plasma Aβ1–40 and Aβ1–42 levels (beta=0.163, P<0.001; beta=0.446, P<0.001).This held in subjective memory complainers (SMC) (Aβ1–40; beta=0.208, P=0.017; Aβ1–42; beta=0.215, P=0.017) but was absent in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) groups. In SMC, increased frequency of the APOE-ε4 allele (beta=0.536, P<0.001) and increasing serum LH levels (beta=0.421, P=0.004) had a significant impact on PiB retention. Whereas in MCI, PiB retention was associated with increased APOE-ε4 allele copy number (beta=0.674, P<0.001) and decreasing calculated free testosterone (beta=−0.303, P=0.043). These findings suggest a potential progressive involvement of LH and testosterone in the early preclinical stages of AD. Furthermore, these hormones should be considered while attempting to predict AD at these earliest stages of the disease. 2014 Journal Article http://hdl.handle.net/20.500.11937/7789 10.1038/mp.2012.147 Nature Publishing Group restricted
repository_type	Digital Repository
institution_category	Local University
institution	Curtin University Malaysia
building	Curtin Institutional Repository
collection	Online Access
description	Testosterone and gonadotropins have been associated with cognitive decline in men and the modulation of β amyloid (Aβ) metabolism. The relatively few studies that have investigated whether changes in one or a combination of these hormones influence Aβ levels have focused primarily on plasma Aβ1–40 and not on the more pathogenic Aβ1–42. Currently, no study has investigated whether these hormones are associated with an increase in brain amyloid deposition, ante mortem. Through the highly characterised Australian imaging, biomarkers and lifestyle study, we have determined the impact of these hormones on plasma Aβ levels and brain amyloid burden (Pittsburgh compound B (PiB) retention). Spearman’s rank correlation and linear regression analysis was carried out across the cohort and within subclassifications. Luteinizing hormone (LH) was the only variable shown, in the total cohort, to have a significant impact on plasma Aβ1–40 and Aβ1–42 levels (beta=0.163, P<0.001; beta=0.446, P<0.001).This held in subjective memory complainers (SMC) (Aβ1–40; beta=0.208, P=0.017; Aβ1–42; beta=0.215, P=0.017) but was absent in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) groups. In SMC, increased frequency of the APOE-ε4 allele (beta=0.536, P<0.001) and increasing serum LH levels (beta=0.421, P=0.004) had a significant impact on PiB retention. Whereas in MCI, PiB retention was associated with increased APOE-ε4 allele copy number (beta=0.674, P<0.001) and decreasing calculated free testosterone (beta=−0.303, P=0.043). These findings suggest a potential progressive involvement of LH and testosterone in the early preclinical stages of AD. Furthermore, these hormones should be considered while attempting to predict AD at these earliest stages of the disease.
format	Journal Article
author	Verdile, Giuseppe Laws, S. Henley, D. Ames, D. Bush, A. Ellis, K. Faux, N. Gupta, V. Li, Q. Masters, C. Pike, K. Rowe, C. Szoeke, C. Taddei, K. Villemagne, V. Martins, R.
spellingShingle	Verdile, Giuseppe Laws, S. Henley, D. Ames, D. Bush, A. Ellis, K. Faux, N. Gupta, V. Li, Q. Masters, C. Pike, K. Rowe, C. Szoeke, C. Taddei, K. Villemagne, V. Martins, R. Associations between gonadotropins, testosterone and [beta] amyloid in men at risk of Alzheimer’s disease
author_facet	Verdile, Giuseppe Laws, S. Henley, D. Ames, D. Bush, A. Ellis, K. Faux, N. Gupta, V. Li, Q. Masters, C. Pike, K. Rowe, C. Szoeke, C. Taddei, K. Villemagne, V. Martins, R.
author_sort	Verdile, Giuseppe
title	Associations between gonadotropins, testosterone and [beta] amyloid in men at risk of Alzheimer’s disease
title_short	Associations between gonadotropins, testosterone and [beta] amyloid in men at risk of Alzheimer’s disease
title_full	Associations between gonadotropins, testosterone and [beta] amyloid in men at risk of Alzheimer’s disease
title_fullStr	Associations between gonadotropins, testosterone and [beta] amyloid in men at risk of Alzheimer’s disease
title_full_unstemmed	Associations between gonadotropins, testosterone and [beta] amyloid in men at risk of Alzheimer’s disease
title_sort	associations between gonadotropins, testosterone and [beta] amyloid in men at risk of alzheimer’s disease
publisher	Nature Publishing Group
publishDate	2014
url	http://hdl.handle.net/20.500.11937/7789
first_indexed	2018-09-06T18:20:24Z
last_indexed	2018-09-06T18:20:24Z
_version_	1610883294731173888

Associations between gonadotropins, testosterone and [beta] amyloid in men at risk of Alzheimer’s disease

Similar Items