Population-based detection of lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial test
Approximately 1-2% of colorectal cancers (CRC) arise because of germline mutations in UNA mismatch repair genes, referred to as Lynch syndrome. These tumours show microsatellite instability (MSI) and loss of expression of mismatch repair proteins. Pre-symptomatic identiication of mutation carriers h...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
John Wiley & Sons, Inc.
2009
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| Online Access: | http://hdl.handle.net/20.500.11937/6157 |