Toxicodynamic Evaluation of a Cisplatin-Chondroitin Sulfate Complex Using a Perfused Kidney and Human Proximal Tubular Cells

Toxicodynamic Evaluation of a Cisplatin-Chondroitin Sulfate Complex Using a Perfused Kidney and Human Proximal Tubular Cells

Cisplatin (CDDP) is an anticancer drug. The clinical limitations associated with CDDP have stimulated the development of macromolecular drug-carrier systems, in attempts to decrease its toxicity. A complex (CDDP-CSA-23) between CDDP and chondroitin sulfate (CSA), a natural polysaccharide with a mean...

Full description

Bibliographic Details
Main Authors: Zhang, J., Kadowaki, D., Nonoguchi, H., Hirata, S., Seo, H., Imai, T., Suenaga, A., Chuang, Victor, Otagiri, M.
Format: Journal Article
Published: Informa Healthcare 2011
Subjects:
nephrotoxicity
human proximal tubular cells
complexation
Chondroitin sulfate
cytotoxicity
cisplatin
perfused kidney
Online Access:http://hdl.handle.net/20.500.11937/44056

Internet

http://hdl.handle.net/20.500.11937/44056

Similar Items