Chemosensitization of solid tumors by inhibition of Bcl-xL expression using DNAzyme.
DNAzymes are a novel class of gene suppressors that selectively bind to an RNA substrate by Watson-Crick base pairing and cleave phosphodiester bonds. To explore the potential for therapeutic use of catalytic DNA molecules, active DNAzymes targeting the bcl-xL gene were generated through a multiplex...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
Impact Journals LLC
2014
|
| Subjects: | |
| Online Access: | http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=1996 http://hdl.handle.net/20.500.11937/29674 |