Rapid determination of Papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection

We have combined high-performance liquid chromatography (HPLC) separations using a monolithic column with acidic potassium permanganate and tris(2,2'-bipyridyl)ruthenium(II) chemiluminescence detection in a rapid and highly sensitive method to monitor the process of extracting opiate alkaloids...

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Main Authors:	Costin, J., Lewis, Simon, Percell, S., Waddell, L., Francis, P., Barnett, N.
Format:	Journal Article
Published:	Elsevier 2007
Subjects:	Alkaloids Chemiluminescence Monolithic column
Online Access:	http://hdl.handle.net/20.500.11937/26948

id	curtin-20.500.11937-26948
recordtype	eprints
spelling	curtin-20.500.11937-269482018-08-08T04:55:20Z Rapid determination of Papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection Costin, J. Lewis, Simon Percell, S. Waddell, L. Francis, P. Barnett, N. Alkaloids Chemiluminescence Monolithic column We have combined high-performance liquid chromatography (HPLC) separations using a monolithic column with acidic potassium permanganate and tris(2,2'-bipyridyl)ruthenium(II) chemiluminescence detection in a rapid and highly sensitive method to monitor the process of extracting opiate alkaloids from Papaver somniferum. Due to the high flow rates allowed with the monolithic column and the inherent selectivity of the chemiluminescence reactions, the four predominant alkaloids - morphine, codeine, oripavine and thebaine - were determined in less than 2 min. The results obtained with numerous process samples compared favourable with those of the standard HPLC methodology. Limits of detection were 11010 M, 51010 M, 51010M and 1109 M, for morphine, codeine, oripavine and thebaine, respectively. 2007 Journal Article http://hdl.handle.net/20.500.11937/26948 10.1016/j.aca.2007.06.044 Elsevier restricted
repository_type	Digital Repository
institution_category	Local University
institution	Curtin University Malaysia
building	Curtin Institutional Repository
collection	Online Access
topic	Alkaloids Chemiluminescence Monolithic column
spellingShingle	Alkaloids Chemiluminescence Monolithic column Costin, J. Lewis, Simon Percell, S. Waddell, L. Francis, P. Barnett, N. Rapid determination of Papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection
description	We have combined high-performance liquid chromatography (HPLC) separations using a monolithic column with acidic potassium permanganate and tris(2,2'-bipyridyl)ruthenium(II) chemiluminescence detection in a rapid and highly sensitive method to monitor the process of extracting opiate alkaloids from Papaver somniferum. Due to the high flow rates allowed with the monolithic column and the inherent selectivity of the chemiluminescence reactions, the four predominant alkaloids - morphine, codeine, oripavine and thebaine - were determined in less than 2 min. The results obtained with numerous process samples compared favourable with those of the standard HPLC methodology. Limits of detection were 11010 M, 51010 M, 51010M and 1109 M, for morphine, codeine, oripavine and thebaine, respectively.
format	Journal Article
author	Costin, J. Lewis, Simon Percell, S. Waddell, L. Francis, P. Barnett, N.
author_facet	Costin, J. Lewis, Simon Percell, S. Waddell, L. Francis, P. Barnett, N.
author_sort	Costin, J.
title	Rapid determination of Papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection
title_short	Rapid determination of Papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection
title_full	Rapid determination of Papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection
title_fullStr	Rapid determination of Papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection
title_full_unstemmed	Rapid determination of Papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection
title_sort	rapid determination of papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection
publisher	Elsevier
publishDate	2007
url	http://hdl.handle.net/20.500.11937/26948
first_indexed	2018-09-06T21:06:34Z
last_indexed	2018-09-06T21:06:34Z
_version_	1610893748788527104

Rapid determination of Papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection

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