Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1
The role of signaling pathways in the regulation of cellular iron metabolism is becoming increasingly recognized. Iron chelation is used for the treatment of iron overload but also as a potential strategy for cancer therapy, because iron depletion results in cell cycle arrest and apoptosis. This stu...
| Main Authors: | , |
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| Format: | Journal Article |
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The American Society for Biochemistry and Molecular Biology Inc
2011
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| Online Access: | http://hdl.handle.net/20.500.11937/26497 |