Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic ß-cell dysfunction and death in vitro.

Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic ß-cell dysfunction and death in vitro.

eHSP72 (extracellular heat-shock protein 72) is increased in the plasma of both types of diabetes and is positively correlated with inflammatory markers. Since aging is associated with a low-grade inflammation and IR (insulin resistance), we aimed to: (i) analyse the concentration of eHSP72 in elder...

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Bibliographic Details
Main Authors: Krause, M., Keane, Kevin, Rodrigues-Krause, J., Crognale, D., Egan, B., De Vito, G., Murphy, C., Newsholme, Philip
Format: Journal Article
Published: Portland Press Ltd. 2013
Subjects:
Type 1 diabetes
extracellular heat-shock protein 72 (eHSP72)
Type 2 diabetes
pancreatic ß-cell
insulin resistance
aging
Online Access:http://hdl.handle.net/20.500.11937/26347

Internet

http://hdl.handle.net/20.500.11937/26347

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