Specific inhibition of ectodomain shedding of glycoprotein lba by targeting its juxtamembrane shedding cleavage site
Background: Ectodomain shedding of glycoprotein Ibα (GPIbα), a proteolytic event in which metalloprotease ADAM17 cleaves the Gly464-Val465 bond and releases glycocalicin to the plasma, is considered a critical step in mediating clearance of stored platelets. Supporting evidence has largely come from...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Published: |
Thieme Medical Publ Inc
2013
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| Online Access: | http://hdl.handle.net/20.500.11937/17298 |