Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice.
Mutations in hemochromatosis protein (HFE) or transferrin receptor 2 (TFR2) cause hereditary hemochromatosis (HH) by impeding production of the liver iron-regulatory hormone, hepcidin (HAMP). This study examined the effects of disruption of Hfe or Tfr2, either alone or together, on liver iron loadin...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Journal Article |
| Published: |
John Wiley & Sons Inc.
2012
|
| Online Access: | http://hdl.handle.net/20.500.11937/13843 |