Free energy of binding of coiled-coil complexes with different electrostatic environments: the influence of force field polarisation and capping
Coiled-coils are well known protein–protein interaction motifs, with the leucine zipper region of activator protein-1 (AP-1) consisting of the c-Jun and c-Fos proteins being a typical example. Molecular dynamics (MD) simulations using the MM/GBSA method have been used to predict the free energy of i...
| Main Authors: | , , |
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| Format: | Journal Article |
| Published: |
Springer
2014
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| Subjects: | |
| Online Access: | http://hdl.handle.net/20.500.11937/12472 |