Titration of signalling output: insights into clinical combinations of MEK and AKT inhibitors

by Stewart, A., Thavasu, P., de Bono, J. S., Banerji, U.
Published 2015

A Joint Model for the Kinetics of CTC Count and PSA Concentration During Treatment in Metastatic Castration-Resistant Prostate Cancer*

by Wilbaux, M, Tod, M, De Bono, J, Lorente, D, Mateo, J, Freyer, G, You, B, Hénin, E
Published 2015

The neutrophil–lymphocyte ratio and its utilisation for the management of cancer patients in early clinical trials

by Kumar, R, Geuna, E, Michalarea, V, Guardascione, M, Naumann, U, Lorente, D, Kaye, S B, de Bono, J S
Published 2015

Impact of cabazitaxel on 2-year survival and palliation of tumour-related pain in men with metastatic castration-resistant prostate cancer treated in the TROPIC trial

by Bahl, A., Oudard, S., Tombal, B., Özgüroĝlu, M., Hansen, S., Kocak, I., Gravis, G., Devin, J., Shen, L., de Bono, J. S., Sartor, A. O.
Published 2013

Antitumour activity of abiraterone and diethylstilboestrol when administered sequentially to men with castration-resistant prostate cancer

by Omlin, A, J Pezaro, C, Zaidi, S, Lorente, D, Mukherji, D, Bianchini, D, Ferraldeschi, R, Sandhu, S, Dearnaley, D, Parker, C, Van As, N, de Bono, J S, Attard, G
Published 2013

Sarcopenia and change in body composition following maximal androgen suppression with abiraterone in men with castration-resistant prostate cancer

by Pezaro, C, Mukherji, D, Tunariu, N, Cassidy, A M, Omlin, A, Bianchini, D, Seed, G, Reid, A H M, Olmos, D, de Bono, J S, Attard, G
Published 2013

Exploratory analysis of the visceral disease subgroup in a phase III study of abiraterone acetate in metastatic castration-resistant prostate cancer

by Goodman, O B, Flaig, T W, Molina, A, Mulders, P F A, Fizazi, K, Suttmann, H, Li, J, Kheoh, T, de Bono, J S, Scher, H I
Published 2014

Reply: ‘Comment on Anti-tumour activity of abiraterone and diethylstilboestrol when administered sequentially to men with castration-resistant prostate cancer'

by Omlin, A, Pezaro, C J, Zaidi, S, Lorente, D, Mukherji, D, Bianchini, D, Ferraldeschi, R, Sandhu, S, Dearnaley, D, Parker, C, Van As, N, de Bono, J S, Attard, G
Published 2014

Creatinine Clearance Is Associated with Toxicity from Molecularly Targeted Agents in Phase I Trials

by Basu, B., Vitfell-Pedersen, J., Moreno Garcia, V., Puglisi, M., Tjokrowidjaja, A., Shah, K., Malvankar, S., Anghan, B., de Bono, J.S., Kaye, S.B., Molife, L.R., Banerji, U.
Published 2012

Complications of hyperglycaemia with PI3K–AKT–mTOR inhibitors in patients with advanced solid tumours on Phase I clinical trials

by Geuna, E, Roda, D, Rafii, S, Jimenez, B, Capelan, M, Rihawi, K, Montemurro, F, Yap, T A, Kaye, S B, De Bono, J S, Molife, L R, Banerji, U
Published 2015

Phase I trial outcomes in older patients with advanced solid tumours

by Khan, K H, Yap, T A, Ring, A, Molife, L R, Bodla, S, Thomas, K, Zivi, A, Smith, A, Judson, I, Banerji, U, de Bono, J S, Kaye, S B
Published 2016

A first-in-human study of the anti-α5β1 integrin monoclonal antibody PF-04605412 administered intravenously to patients with advanced solid tumors

by Mateo, J., Berlin, J., de Bono, J. S., Cohen, R. B., Keedy, V., Mugundu, G., Zhang, Lianglin, Abbattista, A., Davis, C., Gallo Stampino, C., Borghaei, H.
Published 2014

Tumour responses following a steroid switch from prednisone to dexamethasone in castration-resistant prostate cancer patients progressing on abiraterone

by Lorente, D, Omlin, A, Ferraldeschi, R, Pezaro, C, Perez, R, Mateo, J, Altavilla, A, Zafeirou, Z, Tunariu, N, Parker, C, Dearnaley, D, Gillessen, S, de Bono, J, Attard, G
Published 2014

Validation and utilisation of high-coverage next-generation sequencing to deliver the pharmacological audit trail

by Ong, M, Carreira, S, Goodall, J, Mateo, J, Figueiredo, I, Rodrigues, D N, Perkins, G, Seed, G, Yap, T A, Attard, G, de Bono, J S
Published 2014

First-in-human Phase I study of EZN-4176, a locked nucleic acid antisense oligonucleotide to exon 4 of the androgen receptor mRNA in patients with castration-resistant prostate can...

by Bianchini, D, Omlin, A, Pezaro, C, Lorente, D, Ferraldeschi, R, Mukherji, D, Crespo, M, Figueiredo, I, Miranda, S, Riisnaes, R, Zivi, A, Buchbinder, A, Rathkopf, D E, Attard, G, Scher, H I, de Bono, J, Danila, D C
Published 2013

Association of creatine kinase and skin toxicity in phase I trials of anticancer agents

by Moreno Garcia, V, Thavasu, P, Blanco Codesido, M, Molife, L R, Vitfell Pedersen, J, Puglisi, M, Basu, B, Shah, K, Iqbal, J, de Bono, J S, Kaye, S B, Banerji, U
Published 2012

Androgen receptor expression in circulating tumour cells from castration-resistant prostate cancer patients treated with novel endocrine agents

by Crespo, M, van Dalum, G, Ferraldeschi, R, Zafeiriou, Z, Sideris, S, Lorente, D, Bianchini, D, Rodrigues, D N, Riisnaes, R, Miranda, S, Figueiredo, I, Flohr, P, Nowakowska, K, de Bono, J S, Terstappen, L W M M, Attard, G
Published 2015

First-in-man phase I trial of two schedules of the novel synthetic tetrahydroisoquinoline alkaloid PM00104 (Zalypsis) in patients with advanced solid tumours

by Yap, T A, Cortes-Funes, H, Shaw, H, Rodriguez, R, Olmos, D, Lal, R, Fong, P C, Tan, D S, Harris, D, Capdevila, J, Coronado, C, Alfaro, V, Soto-Matos, A, Fernández-Teruel, C, Siguero, M, Tabernero, J M, Paz-Ares, L, de Bono, J S, López-Martin, J A
Published 2012

A prognostic index model for predicting overall survival in patients with metastatic castration-resistant prostate cancer treated with abiraterone acetate after docetaxel

by Chi, K. N., Kheoh, T., Ryan, C. J., Molina, A., Bellmunt, J., Vogelzang, N. J., Rathkopf, D. E., Fizazi, K., Kantoff, P. W., Li, J., Azad, A. A., Eigl, B. J., Heng, D. Y. C., Joshua, A. M., de Bono, J. S., Scher, H. I.
Published 2016

Safety and efficacy of multipolar pulmonary vein ablation catheter vs. irrigated radiofrequency ablation for paroxysmal atrial fibrillation: a randomized multicentre trial

by McCready, J., Chow, A. W., Lowe, M. D., Segal, O. R., Ahsan, S., de Bono, J., Dhaliwal, M., Mfuko, C., Ng, A., Rowland, E. R., Bradley, R. J. W., Paisey, J., Roberts, P., Morgan, J. M., Sandilands, A., Yue, A., Lambiase, P. D.
Published 2014