A Phase I, open-label, dose-escalation study of continuous once-daily oral treatment with afatinib in patients with advanced solid tumors

by Gordon, Michael S., Mendelson, David S., Gross, Mitchell, Uttenreuther-Fischer, Martina, Ould-Kaci, Mahmoud, Zhao, Yihua, Stopfer, Peter, Agus, David B.
Published 2012

A Phase I, open-label, dose escalation study of afatinib, in a 3-week-on/1-week-off schedule in patients with advanced solid tumors

by Marshall, John, Hwang, Jimmy, Eskens, Ferry A. L. M., Burger, Herman, Malik, Shakun, Uttenreuther-Fischer, Martina, Stopfer, Peter, Ould-Kaci, Mahmoud, Cohen, Roger B., Lewis, Nancy L
Published 2012

A phase II study of afatinib, an irreversible ErbB family blocker, added to letrozole in patients with estrogen receptor-positive hormone-refractory metastatic breast cancer progre...

by Gunzer, Katharina, Joly, Florence, Ferrero, Jean-Marc, Gligorov, Joseph, de Mont-Serrat, Helene, Uttenreuther-Fischer, Martina, Pelling, Katy, Wind, Sven, Bousquet, Guilhem, Misset, Jean-Louis
Published 2016

Pharmacokinetics of afatinib in subjects with mild or moderate hepatic impairment

by Schnell, David, Buschke, Susanne, Fuchs, Holger, Gansser, Dietmar, Goeldner, Rainer-Georg, Uttenreuther-Fischer, Martina, Stopfer, Peter, Wind, Sven, Petersen-Sylla, Marc, Halabi, Atef, Koenen, Rüdiger
Published 2014

A phase II study of afatinib (BIBW 2992), an irreversible ErbB family blocker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumab

by Lin, Nancy U., Winer, Eric P., Wheatley, Duncan, Carey, Lisa A., Houston, Stephen, Mendelson, David, Munster, Pamela, Frakes, Laurie, Kelly, Steve, Garcia, Agustin A., Cleator, Susan, Uttenreuther-Fischer, Martina, Jones, Hilary, Wind, Sven, Vinisko, Richard, Hickish, Tamas
Published 2012

A phase II trial to assess efficacy and safety of afatinib in extensively pretreated patients with HER2-negative metastatic breast cancer

by Schuler, Martin, Awada, Ahmad, Harter, Philipp, Canon, Jean Luc, Possinger, Kurt, Schmidt, Marcus, De Grève, Jacques, Neven, Patrick, Dirix, Luc, Jonat, Walter, Beckmann, Matthias W., Schütte, Jochen, Fasching, Peter A., Gottschalk, Nina, Besse-Hammer, Tatiana, Fleischer, Frank, Wind, Sven, Uttenreuther-Fischer, Martina, Piccart, Martine, Harbeck, Nadia
Published 2012

Clonal Evolutionary Analysis during HER2 Blockade in HER2-Positive Inflammatory Breast Cancer: A Phase II Open-Label Clinical Trial of Afatinib +/- Vinorelbine

by Goh, Gerald, Schmid, Ramona, Guiver, Kelly, Arpornwirat, Wichit, Chitapanarux, Imjai, Ganju, Vinod, Im, Seock-Ah, Kim, Sung-Bae, Dechaphunkul, Arunee, Maneechavakajorn, Jedzada, Spector, Neil, Yau, Thomas, Afrit, Mehdi, Ahmed, Slim Ben, Johnston, Stephen R., Gibson, Neil, Uttenreuther-Fischer, Martina, Herrero, Javier, Swanton, Charles
Published 2016