The amyloid hypothesis of Alzheimer's disease at 25 years

by Selkoe, Dennis J, Hardy, John
Published 2016

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

by Bartels, Tim, Choi, Joanna G., Selkoe, Dennis J.
Published 2011

Pen-2 Is Essential for γ-Secretase Complex Stability and Trafficking but Partially Dispensable for Endoproteolysis

by Holmes, Oliver, Paturi, Swetha, Selkoe, Dennis J., Wolfe, Michael S.
Published 2014

N-Alpha-Acetylation of α-Synuclein Increases Its Helical Folding Propensity, GM1 Binding Specificity and Resistance to Aggregation

by Bartels, Tim, Kim, Nora C., Luth, Eric S., Selkoe, Dennis J.
Published 2014

Reducing Amyloid Plaque Burden via Ex Vivo Gene Delivery of an Aβ-Degrading Protease: A Novel Therapeutic Approach to Alzheimer Disease

by Hemming, Matthew L, Patterson, Michaela, Reske-Nielsen, Casper, Lin, Ling, Isacson, Ole, Selkoe, Dennis J
Published 2007

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase

by Bolduc, David M, Montagna, Daniel R, Seghers, Matthew C, Wolfe, Michael S, Selkoe, Dennis J
Published 2016

Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis

by Chen, Allen C., Kim, Sumin, Shepardson, Nina, Patel, Sarvagna, Hong, Soyon, Selkoe, Dennis J.
Published 2015

Purification of α-Synuclein from Human Brain Reveals an Instability of Endogenous Multimers as the Protein Approaches Purity

by Luth, Eric S., Bartels, Tim, Dettmer, Ulf, Kim, Nora C., Selkoe, Dennis J.
Published 2014

A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid

by Yang, Ting, O’Malley, Tiernan T, Kanmert, Daniel, Jerecic, Jasna, Zieske, Lynn R, Zetterberg, Henrik, Hyman, Bradley T, Walsh, Dominic M, Selkoe, Dennis J
Published 2015

Secreted Amyloid β-Proteins in a Cell Culture Model Include N-Terminally Extended Peptides That Impair Synaptic Plasticity

by Welzel, Alfred T., Maggio, John E., Shankar, Ganesh M., Walker, Donald E., Ostaszewski, Beth L., Li, Shaomin, Klyubin, Igor, Rowan, Michael J., Seubert, Peter, Walsh, Dominic M., Selkoe, Dennis J.
Published 2014

Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer’s disease

by Villemagne, Victor L., Klunk, William E., Mathis, Chester A., Rowe, Christopher C., Brooks, David J., Hyman, Bradley T., Ikonomovic, Milos D., Ishii, Kenji, Jack, Clifford R., Jagust, William J., Johnson, Keith A., Koeppe, Robert A., Lowe, Val J., Masters, Colin L., Montine, Thomas J., Morris, John C., Nordberg, Agneta, Petersen, Ronald C., Reiman, Eric M., Selkoe, Dennis J., Sperling, Reisa A., Van Laere, Koen, Weiner, Michael W., Drzezga, Alexander
Published 2012