PCSK9 Prosegment Chimera as Novel Inhibitors of LDLR Degradation

by Luna Saavedra, Yascara Grisel, Zhang, Jianbing, Seidah, Nabil G.
Published 2013

Is there a link between proprotein convertase PC7 activity and human lipid homeostasis?

by Guillemot, Johann, Essalmani, Rachid, Hamelin, Josée, Seidah, Nabil G.
Published 2014

A Novel Mouse Model of Alzheimer's Disease with Chronic Estrogen Deficiency Leads to Glial Cell Activation and Hypertrophy

by Prat, Annik, Behrendt, Maik, Marcinkiewicz, Edwige, Boridy, Sebastien, Sairam, Ram M., Seidah, Nabil G., Maysinger, Dusica
Published 2011

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Can Mediate Degradation of the Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1)

by Canuel, Maryssa, Sun, Xiaowei, Asselin, Marie-Claude, Paramithiotis, Eustache, Prat, Annik, Seidah, Nabil G.
Published 2013

Evidence from a Randomized Trial That Simvastatin, but Not Ezetimibe, Upregulates Circulating PCSK9 Levels

by Berthold, Heiner K., Seidah, Nabil G., Benjannet, Suzanne, Gouni-Berthold, Ioanna
Published 2013

Furin Is the Major Proprotein Convertase Required for KISS1-to-Kisspeptin Processing

by Harihar, Sitaram, Pounds, Keke M., Iwakuma, Tomoo, Seidah, Nabil G., Welch, Danny R.
Published 2014

Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System

by Le Coupanec, Alain, Desforges, Marc, Meessen-Pinard, Mathieu, Dubé, Mathieu, Day, Robert, Seidah, Nabil G., Talbot, Pierre J.
Published 2015

Chloroquine is a potent inhibitor of SARS coronavirus infection and spread

by Vincent, Martin J, Bergeron, Eric, Benjannet, Suzanne, Erickson, Bobbie R, Rollin, Pierre E, Ksiazek, Thomas G, Seidah, Nabil G, Nichol, Stuart T
Published 2005

Annexin A2 Is a Natural Extrahepatic Inhibitor of the PCSK9-Induced LDL Receptor Degradation

by Seidah, Nabil G., Poirier, Steve, Denis, Maxime, Parker, Rex, Miao, Bowman, Mapelli, Claudio, Prat, Annik, Wassef, Hanny, Davignon, Jean, Hajjar, Katherine A., Mayer, Gaétan
Published 2012

Modulation of Protease Activated Receptor 1 Influences Human Metapneumovirus Disease Severity in a Mouse Model

by Aerts, Laetitia, Hamelin, Marie-Ève, Rhéaume, Chantal, Lavigne, Sophie, Couture, Christian, Kim, WooJin, Susan-Resiga, Delia, Prat, Annik, Seidah, Nabil G., Vergnolle, Nathalie, Riteau, Beatrice, Boivin, Guy
Published 2013

Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth

by Declercq, Jeroen, Brouwers, Bas, Pruniau, Vincent P. E. G., Stijnen, Pieter, Tuand, Krizia, Meulemans, Sandra, Prat, Annik, Seidah, Nabil G., Khatib, Abdel-Majid, Creemers, John W. M.
Published 2015

Decreased PCSK9 expression in human hepatocellular carcinoma

by Bhat, Mamatha, Skill, Nicolas, Marcus, Victoria, Deschenes, Marc, Tan, Xianming, Bouteaud, Jeanne, Negi, Sarita, Awan, Zuhier, Aikin, Reid, Kwan, Janet, Amre, Ramila, Tabaries, Sebastien, Hassanain, Mazen, Seidah, Nabil G., Maluccio, Mary, Siegel, Peter, Metrakos, Peter
Published 2015

Automated design of ligands to polypharmacological profiles

by Besnard, Jérémy, Ruda, Gian Filippo, Setola, Vincent, Abecassis, Keren, Rodriguiz, Ramona M., Huang, Xi-Ping, Norval, Suzanne, Sassano, Maria F., Shin, Antony I., Webster, Lauren A., Simeons, Frederick R.C., Stojanovski, Laste, Prat, Annik, Seidah, Nabil G., Constam, Daniel B., Bickerton, G. Richard, Read, Kevin D., Wetsel, William C., Gilbert, Ian H., Roth, Bryan L., Hopkins, Andrew L.
Published 2012