The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation

by Zhang, Yong-Jie, Caulfield, Thomas, Xu, Ya-Fei, Gendron, Tania F., Hubbard, Jaime, Stetler, Caroline, Sasaguri, Hiroki, Whitelaw, Ena C., Cai, Shuyi, Lee, Wing Cheung, Petrucelli, Leonard
Published 2013

Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43

by Uchida, Azusa, Sasaguri, Hiroki, Kimura, Nobuyuki, Tajiri, Mio, Ohkubo, Takuya, Ono, Fumiko, Sakaue, Fumika, Kanai, Kazuaki, Hirai, Takashi, Sano, Tatsuhiko, Shibuya, Kazumoto, Kobayashi, Masaki, Yamamoto, Mariko, Yokota, Shigefumi, Kubodera, Takayuki, Tomori, Masaki, Sakaki, Kyohei, Enomoto, Mitsuhiro, Hirai, Yukihiko, Kumagai, Jiro, Yasutomi, Yasuhiro, Mochizuki, Hideki, Kuwabara, Satoshi, Uchihara, Toshiki, Mizusawa, Hidehiro, Yokota, Takanori
Published 2012

Targeted manipulation of the sortilin–progranulin axis rescues progranulin haploinsufficiency

by Lee, Wing C., Almeida, Sandra, Prudencio, Mercedes, Caulfield, Thomas R., Zhang, Yong-Jie, Tay, William M., Bauer, Peter O., Chew, Jeannie, Sasaguri, Hiroki, Jansen-West, Karen R., Gendron, Tania F., Stetler, Caroline T., Finch, NiCole, Mackenzie, Ian R., Rademakers, Rosa, Gao, Fen-Biao, Petrucelli, Leonard
Published 2014

Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress

by Zhang, Yong-Jie, Jansen-West, Karen, Xu, Ya-Fei, Gendron, Tania F., Bieniek, Kevin F., Lin, Wen-Lang, Sasaguri, Hiroki, Caulfield, Thomas, Hubbard, Jaime, Daughrity, Lillian, Chew, Jeannie, Belzil, Veronique V., Prudencio, Mercedes, Stankowski, Jeannette N., Castanedes-Casey, Monica, Whitelaw, Ena, Ash, Peter E. A., DeTure, Michael, Rademakers, Rosa, Boylan, Kevin B., Dickson, Dennis W., Petrucelli, Leonard
Published 2014