BCR and its mutants, the reciprocal t(9;22)-associated ABL/BCR fusion proteins, differentially regulate the cytoskeleton and cell motility

by Zheng, Xiaomin, Güller, Saskia, Beissert, Tim, Puccetti, Elena, Ruthardt, Martin
Published 2006

Sulindac Sulfide Reverses Aberrant Self-Renewal of Progenitor Cells Induced by the AML-Associated Fusion Proteins PML/RARα and PLZF/RARα

by Steinert, Gunnar, Oancea, Claudia, Roos, Jessica, Hagemeyer, Heike, Maier, Thorsten, Ruthardt, Martin, Puccetti, Elena
Published 2011

Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism

by Khateb, Mamduh, Ruimi, Nili, Khamisie, Hazem, Najajreh, Yousef, Mian, Afsar, Metodieva, Anna, Ruthardt, Martin, Mahajna, Jamal
Published 2012

Platinum (IV)-fatty acid conjugates overcome inherently and acquired Cisplatin resistant cancer cell lines: an in-vitro study

by Ratzon, Einav, Najajreh, Yousef, Salem, Rami, Khamaisie, Hazem, Ruthardt, Martin, Mahajna, Jamal
Published 2016

BCR: a new target in resistance mediated by BCR/ABL-315I?

by Haberbosch, Isabella, Rafiei, Anahita, Oancea, Claudia, Ottmann, Gerhart Oliver, Ruthardt, Martin, Mian, Afsar Ali
Published 2016

5-Lipoxygenase: Underappreciated Role of a Pro-Inflammatory Enzyme in Tumorigenesis

by Steinhilber, Dieter, Fischer, Astrid Stefanie, Metzner, Julia, Steinbrink, Svenja Dorothea, Roos, Jessica, Ruthardt, Martin, Maier, Thorsten Jürgen
Published 2010

Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I

by Mian, Afsar Ali, Metodieva, Anna, Badura, Susanne, Khateb, Mamduh, Ruimi, Nili, Najajreh, Yousef, Ottmann, Oliver Gerhard, Mahajna, Jamal, Ruthardt, Martin
Published 2012

Differential Effects of Selective Inhibitors Targeting the PI3K/AKT/mTOR Pathway in Acute Lymphoblastic Leukemia

by Badura, Susanne, Tesanovic, Tamara, Pfeifer, Heike, Wystub, Sylvia, Nijmeijer, Bart A., Liebermann, Marcus, Falkenburg, J. H. Frederik, Ruthardt, Martin, Ottmann, Oliver G.
Published 2013

The Functional Interplay Between the t(9;22)-Associated Fusion Proteins BCR/ABL and ABL/BCR in Philadelphia Chromosome-Positive Acute Lymphatic Leukemia

by Rafiei, Anahita, Mian, Afsar Ali, Döring, Claudia, Metodieva, Anna, Oancea, Claudia, Thalheimer, Frederic B., Hansmann, Martin Leo, Ottmann, Oliver Gerhard, Ruthardt, Martin
Published 2015

STAT activation status differentiates leukemogenic from non-leukemogenic stem cells in AML and is suppressed by arsenic in t(6;9)-positive AML

by Oancea, Claudia, Rüster, Brigitte, Brill, Boris, Roos, Jessica, Heinssmann, Maria, Bug, Gesine, Mian, Afsar Ali, Guillen, Nathalie Andrea, Kornblau, Steven M., Henschler, Reinhard, Ruthardt, Martin
Published 2014