The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8+ T cells into innate-like effector cells with antitumor activity

by Wong, Hing C, Jeng, Emily K, Rhode, Peter R
Published 2013

Enhanced efficacy of IL-15-based ALT-803 superagonist complex in combination with immune checkpoint inhibitors in hematologic and metastatic mouse tumor models

by Xu, Wenxin, Marcus, Warren D, Rhode, Peter R, Wong, Hing C
Published 2014

A phase I study evaluating the pharmacokinetics, safety and tolerability of an antibody-based tissue factor antagonist in subjects with acute lung injury or acute respiratory distr...

by Morris, Peter E, Steingrub, Jay S, Huang, Bee Y, Tang, Shamay, Liu, Patrick M, Rhode, Peter R, Wong, Hing C
Published 2012

Enhanced efficacy of ALT-803, an IL-15-based superagonist complex, in combination with immune checkpoint inhibitors in an orthotopic muscle invasive bladder tumor model in mice

by Xu, Wenxin, Kage, Karen, Marcus, Warren D, Newman, Robby, Alter, Sarah, Rhode, Peter R, Wong, Hing C
Published 2015

Evaluation of a novel CD20-targeted IL-15 immunotherapeutic with potent activity against B cell lymphoma

by Liu, Bai, Kong, Lin, Marcus, Warren D, Chen, Xiaoyue, Han, Kaiping, Rhode, Peter R, Wong, Hing C
Published 2014

CITN-06: a Phase I/expansion trial of alt-803, an IL-15 superagonist, in patients with advanced melanoma

by Margolin, Kim, Wong, Hing C, Morishima, Chihiro, Hernandez, Liza, Ernstoff, Marc, Rhode, Peter R, Waldmann, Thomas A
Published 2014

Combination therapy of an IL-15 superagonist complex, ALT-803, and a tumor targeting monoclonal antibody promotes direct antitumor activity and protective vaccinal effect in a syng...

by Chen, Xiaoyue, Liu, Bai, Han, Kaiping, Kong, Lin, Noel, Terra, Jeng, Emily K, Alter, Sarah, Rubinstein, Mark, Rhode, Peter R, Wong, Hing C
Published 2015

The IL-15 superagonist ALT-803 enhances anti-CD20 antibody-directed NK cell ADCC and in vivo clearance of B cell lymphomas

by Rosario, Maximillian, Liu, Bai, Kong, Lin, Schneider, Stephanie E, Jeng, Emily K, Rhode, Peter R, Wong, Hing C, Fehniger, Todd A
Published 2014

Intravesical ALT-803 and BCG Treatment Reduces Tumor Burden in a Carcinogen Induced Bladder Cancer Rat Model; a Role for Cytokine Production and NK Cell Expansion

by Gomes-Giacoia, Evan, Miyake, Makito, Goodison, Steve, Sriharan, Aravindhan, Zhang, Ge, You, Lijing, Egan, Jack O., Rhode, Peter R., Parker, Alexander S., Chai, Karl X., Wong, Hing C., Rosser, Charles J.
Published 2014

Novel antitumor mechanism-of-action of an IL-2 fusion protein mediated by tumor associated macrophage repolarization and innate-like CD8+ memory T cells

by Xu, Wenxin, Egan, Jack O, Liu, Bai, Chen, Xiaoyue, You, Lijing, Han, Kaiping, Marcus, Warren D, Kong, Lin, Jones, Monica, Jeng, Emily K, Rhode, Peter R, Wong, Hing C
Published 2014