Epigenetics in Friedreich's Ataxia: Challenges and Opportunities for Therapy

by Sandi, Chiranjeevi, Al-Mahdawi, Sahar, Pook, Mark A.
Published 2013

The emerging role of 5-hydroxymethylcytosine in neurodegenerative diseases

by Al-Mahdawi, Sahar, Virmouni, Sara Anjomani, Pook, Mark A.
Published 2014

Friedreich Ataxia Patient Tissues Exhibit Increased 5-Hydroxymethylcytosine Modification and Decreased CTCF Binding at the FXN Locus

by Al-Mahdawi, Sahar, Sandi, Chiranjeevi, Mouro Pinto, Ricardo, Pook, Mark A.
Published 2013

Epigenetic-based therapies for Friedreich ataxia

by Sandi, Chiranjeevi, Sandi, Madhavi, Anjomani Virmouni, Sara, Al-Mahdawi, Sahar, Pook, Mark A.
Published 2014

MutLα Heterodimers Modify the Molecular Phenotype of Friedreich Ataxia

by Ezzatizadeh, Vahid, Sandi, Chiranjeevi, Sandi, Madhavi, Anjomani-Virmouni, Sara, Al-Mahdawi, Sahar, Pook, Mark A.
Published 2014

Comparative (Computational) Analysis of the DNA Methylation Status of Trinucleotide Repeat Expansion Diseases

by Ghorbani, Mohammadmersad, Taylor, Simon J. E., Pook, Mark A., Payne, Annette
Published 2013

Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia

by Hayashi, Genki, Shen, Yan, Pedersen, Theresa L., Newman, John W., Pook, Mark, Cortopassi, Gino
Published 2014

Cellular, Molecular and Functional Characterisation of YAC Transgenic Mouse Models of Friedreich Ataxia

by Anjomani Virmouni, Sara, Sandi, Chiranjeevi, Al-Mahdawi, Sahar, Pook, Mark A.
Published 2014

Pharmacological Screening Using an FXN-EGFP Cellular Genomic Reporter Assay for the Therapy of Friedreich Ataxia

by Li, Lingli, Voullaire, Lucille, Sandi, Chiranjeevi, Pook, Mark A., Ioannou, Panos A., Delatycki, Martin B., Sarsero, Joseph P.
Published 2013

Pms2 Suppresses Large Expansions of the (GAA·TTC)n Sequence in Neuronal Tissues

by Bourn, Rebecka L., De Biase, Irene, Pinto, Ricardo Mouro, Sandi, Chiranjeevi, Al-Mahdawi, Sahar, Pook, Mark A., Bidichandani, Sanjay I.
Published 2012

Generation and Characterisation of Friedreich Ataxia YG8R Mouse Fibroblast and Neural Stem Cell Models

by Sandi, Chiranjeevi, Sandi, Madhavi, Jassal, Harvinder, Ezzatizadeh, Vahid, Anjomani-Virmouni, Sara, Al-Mahdawi, Sahar, Pook, Mark A.
Published 2014

Identification of telomere dysfunction in Friedreich ataxia

by Anjomani Virmouni, Sara, Al-Mahdawi, Sahar, Sandi, Chiranjeevi, Yasaei, Hemad, Giunti, Paola, Slijepcevic, Predrag, Pook, Mark A.
Published 2015

A novel GAA-repeat-expansion-based mouse model of Friedreich’s ataxia

by Anjomani Virmouni, Sara, Ezzatizadeh, Vahid, Sandi, Chiranjeevi, Sandi, Madhavi, Al-Mahdawi, Sahar, Chutake, Yogesh, Pook, Mark A.
Published 2015

Interferon gamma upregulates frataxin and corrects the functional deficits in a Friedreich ataxia model

by Tomassini, Barbara, Arcuri, Gaetano, Fortuni, Silvia, Sandi, Chiranjeevi, Ezzatizadeh, Vahid, Casali, Carlo, Condò, Ivano, Malisan, Florence, Al-Mahdawi, Sahar, Pook, Mark, Testi, Roberto
Published 2012

Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model

by Sandi, Chiranjeevi, Pinto, Ricardo Mouro, Al-Mahdawi, Sahar, Ezzatizadeh, Vahid, Barnes, Glenn, Jones, Steve, Rusche, James R., Gottesfeld, Joel M., Pook, Mark A.
Published 2011

Novel Frataxin Isoforms May Contribute to the Pathological Mechanism of Friedreich Ataxia

by Xia, Haiyan, Cao, Yun, Dai, Xiaoman, Marelja, Zvonimir, Zhou, Di, Mo, Ran, Al-Mahdawi, Sahar, Pook, Mark A., Leimkühler, Silke, Rouault, Tracey A., Li, Kuanyu
Published 2012

FXN Promoter Silencing in the Humanized Mouse Model of Friedreich Ataxia

by Chutake, Yogesh K., Costello, Whitney N., Lam, Christina C., Parikh, Aniruddha C., Hughes, Tamara T., Michalopulos, Michael G., Pook, Mark A., Bidichandani, Sanjay I.
Published 2015

Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia

by Sahdeo, Sunil, Scott, Brian D., McMackin, Marissa Z., Jasoliya, Mittal, Brown, Brandon, Wulff, Heike, Perlman, Susan L., Pook, Mark A., Cortopassi, Gino A.
Published 2014