Therapy-induced tumour secretomes promote resistance and tumour progression

by Obenauf, Anna C., Zou, Yilong, Ji, Andrew L., Vanharanta, Sakari, Shu, Weiping, Shi, Hubing, Kong, Xiangju, Bosenberg, Marcus C., Wiesner, Thomas, Rosen, Neal, Lo, Roger S., Massagué, Joan
Published 2015

Melanoma whole exome sequencing identifies V600EB-RAF amplification-mediated acquired B-RAF inhibitor resistance

by Shi, Hubing, Moriceau, Gatien, Kong, Xiangju, Lee, Mi-Kyung, Lee, Hane, Koya, Richard C., Ng, Charles, Chodon, Thinle, Scolyer, Richard A., Dahlman, Kimberly B., Sosman, Jeffrey A., Kefford, Richard F., Long, Georgina V., Nelson, Stanley F., Ribas, Antoni, Lo, Roger S.
Published 2012

Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors

by Marusiak, Anna A., Edwards, Zoe C., Hugo, Willy, Trotter, Eleanor W., Girotti, Maria R., Stephenson, Natalie L., Kong, Xiangju, Gartside, Michael G., Fawdar, Shameem, Hudson, Andrew, Breitwieser, Wolfgang, Hayward, Nicholas K., Marais, Richard, Lo, Roger S., Brognard, John
Published 2014

JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma

by Titz, Bjoern, Lomova, Anastasia, Le, Allison, Hugo, Willy, Kong, Xiangju, ten Hoeve, Johanna, Friedman, Michael, Shi, Hubing, Moriceau, Gatien, Song, Chunying, Hong, Aayoung, Atefi, Mohammad, Li, Richard, Komisopoulou, Evangelia, Ribas, Antoni, Lo, Roger S, Graeber, Thomas G
Published 2016

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

by Poulikakos, Poulikos I., Persaud, Yogindra, Janakiraman, Manickam, Kong, Xiangju, Ng, Charles, Moriceau, Gatien, Shi, Hubing, Atefi, Mohammad, Titz, Bjoern, Gabay, May Tal, Salton, Maayan, Dahlman, Kimberly B., Tadi, Madhavi, Wargo, Jennifer A., Flaherty, Keith T., Kelley, Mark C., Misteli, Tom, Chapman, Paul B., Sosman, Jeffrey A., Graeber, Thomas G., Ribas, Antoni, Lo, Roger S., Rosen, Neal, Solit, David B.
Published 2011