Systems biology-guided identification of synthetic lethal gene pairs and its potential use to discover antibiotic combinations

by Aziz, Ramy K., Monk, Jonathan M., Lewis, Robert M., In Loh, Suh, Mishra, Arti, Abhay Nagle, Amrita, Satyanarayana, Chitkala, Dhakshinamoorthy, Saravanakumar, Luche, Michele, Kitchen, Douglas B., Andrews, Kathleen A., Fong, Nicole L., Li, Howard J., Palsson, Bernhard O., Charusanti, Pep
Published 2015

Model-driven discovery of synergistic inhibitors against E. coli and S. enterica serovar Typhimurium targeting a novel synthetic lethal pair, aldA and prpC

by Aziz, Ramy K., Khaw, Valerie L., Monk, Jonathan M., Brunk, Elizabeth, Lewis, Robert, Loh, Suh I., Mishra, Arti, Nagle, Amrita A., Satyanarayana, Chitkala, Dhakshinamoorthy, Saravanakumar, Luche, Michele, Kitchen, Douglas B., Andrews, Kathleen A., Palsson, Bernhard Ø., Charusanti, Pep
Published 2015

Design, Synthesis, and Evaluation of Nonretinoid Retinol Binding Protein 4 Antagonists for the Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Diseas...

by Cioffi, Christopher L., Dobri, Nicoleta, Freeman, Emily E., Conlon, Michael P., Chen, Ping, Stafford, Douglas G., Schwarz, Daniel M. C., Golden, Kathy C., Zhu, Lei, Kitchen, Douglas B., Barnes, Keith D., Racz, Boglarka, Qin, Qiong, Michelotti, Enrique, Cywin, Charles L., Martin, William H., Pearson, Paul G., Johnson, Graham, Petrukhin, Konstantin
Published 2014