Systemic delivery of liposome-anchored anti-CD137 and IL2-Fc prevents lethal toxicity and elicits potent antitumor immunity

by Zhang, Yuan, Irvine, Darrell J
Published 2015

Membrane Anchored Immunostimulatory Oligonucleotides for In Vivo Cell Modification and Localized Immunotherapy**

by Liu, Haipeng, Kwong, Brandon, Irvine, Darrell J
Published 2011

Synergistic Antitumor Activity from Two-Stage Delivery of Targeted Toxins and Endosome-Disrupting Nanoparticles

by Su, Xingfang, Yang, Nicole, Wittrup, K. Dane, Irvine, Darrell J.
Published 2013

T lymphocyte engineering with cytokine nanogels for enhanced cancer immunotherapy

by Tang, Li, Zheng, Yiran, Mabardi, Llian, Irvine, Darrell J
Published 2015

Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8+ T cells

by Palmer, Megan J, Mahajan, Vinay S, Chen, Jianzhu, Irvine, Darrell J, Lauffenburger, Douglas A
Published 2011

Antigen-Displaying Lipid-Enveloped PLGA Nanoparticles as Delivery Agents for a Plasmodium vivax Malaria Vaccine

by Moon, James J., Suh, Heikyung, Polhemus, Mark E., Ockenhouse, Christian F., Yadava, Anjali, Irvine, Darrell J.
Published 2012

Block Copolymer Micelles as Nanocontainers for Controlled Release of Proteins from Biocompatible Oil Phases

by Miller, Andrew C., Bershteyn, Anna, Tan, Wuisiew, Hammond, Paula T., Cohen, Robert E., Irvine, Darrell J.
Published 2009

Antigen Delivery by Lipid-Enveloped PLGA Microparticle Vaccines Mediated by in Situ Vesicle Shedding

by Hanson, Melissa C., Bershteyn, Anna, Crespo, Monica P., Irvine, Darrell J.
Published 2014

Design of Lipid Nanocapsule Delivery Vehicles for Multivalent Display of Recombinant Env Trimers in HIV Vaccination

by Pejawar-Gaddy, Sharmila, Kovacs, James M., Barouch, Dan H., Chen, Bing, Irvine, Darrell J.
Published 2014

High Avidity CD8+ T Cells Efficiently Eliminate Motile HIV-Infected Targets and Execute a Locally Focused Program of Anti-Viral Function

by Foley, Maria Hottelet, Forcier, Talitha, McAndrew, Elizabeth, Gonzalez, Michael, Chen, Huabiao, Juelg, Boris, Walker, Bruce D., Irvine, Darrell J.
Published 2014

Composite Dissolving Microneedles for Coordinated Control of Antigen and Adjuvant Delivery Kinetics in Transcutaneous Vaccination

by DeMuth, Peter C, Garcia-Beltran, Wilfredo F, Ai-Ling, Michelle Lim, Hammond, Paula T, Irvine, Darrell J
Published 2013

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

by Kumari, Sudha, Depoil, David, Martinelli, Roberta, Judokusumo, Edward, Carmona, Guillaume, Gertler, Frank B, Kam, Lance C, Carman, Christopher V, Burkhardt, Janis K, Irvine, Darrell J, Dustin, Michael L
Published 2015

Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies

by Wang, Shenshen, Mata-Fink, Jordi, Kriegsman, Barry, Hanson, Melissa, Irvine, Darrell J., Eisen, Herman N., Burton, Dennis R., Wittrup, K. Dane, Kardar, Mehran, Chakraborty, Arup K.
Published 2015

Interbilayer-Crosslinked Multilamellar Vesicles as Synthetic Vaccines for Potent Humoral and Cellular Immune Responses

by Moon, James J., Suh, Heikyung, Bershteyn, Anna, Stephan, Matthias T., Liu, Haipeng, Huang, Bonnie, Sohail, Mashaal, Luo, Samantha, Um, Soong Ho, Khant, Htet, Goodwin, Jessica T., Ramos, Jenelyn, Chiu, Wah, Irvine, Darrell J.
Published 2011

Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy

by Griffiths, Kristin L., Ahmed, Mushtaq, Das, Shibali, Gopal, Radha, Horne, William, Connell, Terry D., Moynihan, Kelly D., Kolls, Jay K., Irvine, Darrell J., Artyomov, Maxim N., Rangel-Moreno, Javier, Khader, Shabaana A.
Published 2016

Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines

by Lee Szeto, Gregory, Van Egeren, Debra, Worku, Hermoon, Sharei, Armon, Alejandro, Brian, Park, Clara, Frew, Kirubel, Brefo, Mavis, Mao, Shirley, Heimann, Megan, Langer, Robert, Jensen, Klavs, Irvine, Darrell J
Published 2015

A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages

by Kimmerling, Robert J., Lee Szeto, Gregory, Li, Jennifer W., Genshaft, Alex S., Kazer, Samuel W., Payer, Kristofor R., de Riba Borrajo, Jacob, Blainey, Paul C., Irvine, Darrell J., Shalek, Alex K., Manalis, Scott R.
Published 2016

Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes

by Jones, Richard Brad, O'Connor, Rachel, Mueller, Stefanie, Foley, Maria, Szeto, Gregory L., Karel, Dan, Lichterfeld, Mathias, Kovacs, Colin, Ostrowski, Mario A., Trocha, Alicja, Irvine, Darrell J., Walker, Bruce D.
Published 2014

Vaccine delivery with microneedle skin patches in nonhuman primates

by DeMuth, Peter C., Li, Adrienne V., Abbink, Peter, Liu, Jinyan, Li, Hualin, Stanley, Kelly A., Smith, Kaitlin M., Lavine, Christy L., Seaman, Michael S., Kramer, Joshua A., Miller, Andrew D., Abraham, Wuhbet, Suh, Heikyung, Elkhader, Jamal, Hammond, Paula T., Barouch, Dan H., Irvine, Darrell J.
Published 2013

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

by Steichen, Jon M., Kulp, Daniel W., Tokatlian, Talar, Escolano, Amelia, Dosenovic, Pia, Stanfield, Robyn L., McCoy, Laura E., Ozorowski, Gabriel, Hu, Xiaozhen, Kalyuzhniy, Oleksandr, Briney, Bryan, Schiffner, Torben, Garces, Fernando, Freund, Natalia T., Gitlin, Alexander D., Menis, Sergey, Georgeson, Erik, Kubitz, Michael, Adachi, Yumiko, Jones, Meaghan, Mutafyan, Andrew A., Yun, Dong Soo, Mayer, Christian T., Ward, Andrew B., Burton, Dennis R., Wilson, Ian A., Irvine, Darrell J., Nussenzweig, Michel C., Schief, William R.
Published 2016