Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists

by Ajram, Laura, Begg, Malcolm, Slack, Robert, Cryan, Jenni, Hall, David, Hodgson, Simon, Ford, Alison, Barnes, Ashley, Swieboda, Dawid, Mousnier, Aurelie, Solari, Roberto
Published 2014

Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a ran...

by Cahn, Anthony, Hodgson, Simon, Wilson, Robert, Robertson, Jonathan, Watson, Joanna, Beerahee, Misba, Hughes, Steve C, Young, Graeme, Graves, Rebecca, Hall, David, van Marle, Sjoerd, Solari, Roberto
Published 2013

Antagonism of human CC-chemokine receptor 4 can be achieved through three distinct binding sites on the receptor

by Slack, Robert J, Russell, Linda J, Barton, Nick P, Weston, Cathryn, Nalesso, Giovanna, Thompson, Sally-Anne, Allen, Morven, Chen, Yu Hua, Barnes, Ashley, Hodgson, Simon T, Hall, David A
Published 2013

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014

by Heifetz, Alexander, Schertler, Gebhard F. X., Seifert, Roland, Tate, Christopher G., Sexton, Patrick M., Gurevich, Vsevolod V., Fourmy, Daniel, Cherezov, Vadim, Marshall, Fiona H., Storer, R. Ian, Moraes, Isabel, Tikhonova, Irina G., Tautermann, Christofer S., Hunt, Peter, Ceska, Tom, Hodgson, Simon, Bodkin, Mike J., Singh, Shweta, Law, Richard J., Biggin, Philip C.
Published 2015