Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice

by Thorel, Fabrizio, Damond, Nicolas, Chera, Simona, Wiederkehr, Andreas, Thorens, Bernard, Meda, Paolo, Wollheim, Claes B., Herrera, Pedro L.
Published 2011

In Situ Electrophysiological Examination of Pancreatic α Cells in the Streptozotocin-Induced Diabetes Model, Revealing the Cellular Basis of Glucagon Hypersecretion

by Huang, Ya-Chi, Rupnik, Marjan S., Karimian, Negar, Herrera, Pedro L., Gilon, Patrick, Feng, Zhong-Ping, Gaisano, Herbert Y.
Published 2013

Nogo-A Downregulation Improves Insulin Secretion in Mice

by Bonal, Claire B., Baronnier, Delphine E., Pot, Caroline, Benkhoucha, Mahdia, Schwab, Martin E., Lalive, Patrice H., Herrera, Pedro L.
Published 2013

Loss of Prohibitin Induces Mitochondrial Damages Altering β-Cell Function and Survival and Is Responsible for Gradual Diabetes Development

by Supale, Sachin, Thorel, Fabrizio, Merkwirth, Carsten, Gjinovci, Asllan, Herrera, Pedro L., Scorrano, Luca, Meda, Paolo, Langer, Thomas, Maechler, Pierre
Published 2013

Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist

by Damond, Nicolas, Thorel, Fabrizio, Moyers, Julie S, Charron, Maureen J, Vuguin, Patricia M, Powers, Alvin C, Herrera, Pedro L
Published 2016

Dicer Is Required for Haploid Male Germ Cell Differentiation in Mice

by Korhonen, Hanna M., Meikar, Oliver, Yadav, Ram Prakash, Papaioannou, Marilena D., Romero, Yannick, Da Ros, Matteo, Herrera, Pedro L., Toppari, Jorma, Nef, Serge, Kotaja, Noora
Published 2011

Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD–scid IL-2rgnull RIP-DTR mice engrafted with...

by Yang, Chaoxing, Loehn, Matthias, Jurczyk, Agata, Przewozniak, Natalia, Leehy, Linda, Herrera, Pedro L, Shultz, Leonard D, Greiner, Dale L, Harlan, David M, Bortell, Rita
Published 2015

The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion*

by Solomou, Antonia, Meur, Gargi, Bellomo, Elisa, Hodson, David J., Tomas, Alejandra, Migrenne Li, Stéphanie, Philippe, Erwann, Herrera, Pedro L., Magnan, Christophe, Rutter, Guy A.
Published 2015

Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells

by Paul, Leena, Walker, Emily M., Drosos, Yiannis, Cyphert, Holly A., Neale, Geoffrey, Stein, Roland, South, Jack, Grosveld, Gerard, Herrera, Pedro L., Sosa-Pineda, Beatriz
Published 2016

Connective Tissue Growth Factor Modulates Adult β-Cell Maturity and Proliferation to Promote β-Cell Regeneration in Mice

by Riley, Kimberly G., Pasek, Raymond C., Maulis, Matthew F., Peek, Jennifer, Thorel, Fabrizio, Brigstock, David R., Herrera, Pedro L., Gannon, Maureen
Published 2015

Diabetes Recovery By Age-Dependent Conversion of Pancreatic δ-Cells Into Insulin Producers

by Chera, Simona, Baronnier, Delphine, Ghila, Luiza, Cigliola, Valentina, Jensen, Jan N., Gu, Guoqiang, Furuyama, Kenichiro, Thorel, Fabrizio, Gribble, Fiona M., Reimann, Frank, Herrera, Pedro L.
Published 2014

In Vivo Conditional Pax4 Overexpression in Mature Islet β-Cells Prevents Stress-Induced Hyperglycemia in Mice

by He, Kai Hui Hu, Lorenzo, Petra I., Brun, Thierry, Jimenez Moreno, Carmen M., Aeberhard, Deborah, Ortega, Jorge Vallejo, Cornu, Marion, Thorel, Fabrizio, Gjinovci, Asllan, Thorens, Bernard, Herrera, Pedro L., Meda, Paolo, Wollheim, Claes B., Gauthier, Benoit R.
Published 2011

UCP2 Regulates the Glucagon Response to Fasting and Starvation

by Allister, Emma M., Robson-Doucette, Christine A., Prentice, Kacey J., Hardy, Alexandre B., Sultan, Sobia, Gaisano, Herbert Y., Kong, Dong, Gilon, Patrick, Herrera, Pedro L., Lowell, Bradford B., Wheeler, Michael B.
Published 2013

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity

by Schaffer, Ashleigh E., Taylor, Brandon L., Benthuysen, Jacqueline R., Liu, Jingxuan, Thorel, Fabrizio, Yuan, Weiping, Jiao, Yang, Kaestner, Klaus H., Herrera, Pedro L., Magnuson, Mark A., May, Catherine Lee, Sander, Maike
Published 2013

Argonaute2 Mediates Compensatory Expansion of the Pancreatic β Cell

by Tattikota, Sudhir G., Rathjen, Thomas, McAnulty, Sarah J., Wessels, Hans-Hermann, Akerman, Ildem, van de Bunt, Martijn, Hausser, Jean, Esguerra, Jonathan L.S., Musahl, Anne, Pandey, Amit K., You, Xintian, Chen, Wei, Herrera, Pedro L., Johnson, Paul R., O’Carroll, Donal, Eliasson, Lena, Zavolan, Mihaela, Gloyn, Anna L., Ferrer, Jorge, Shalom-Feuerstein, Ruby, Aberdam, Daniel, Poy, Matthew N.
Published 2014

Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production

by Semplici, Francesca, Mondragon, Angeles, Macintyre, Benedict, Madeyski-Bengston, Katja, Persson-Kry, Anette, Barr, Sara, Ramne, Anna, Marley, Anna, McGinty, James, French, Paul, Soedling, Helen, Yokosuka, Ryohsuke, Gaitan, Julien, Lang, Jochen, Migrenne-Li, Stephanie, Philippe, Erwann, Herrera, Pedro L., Magnan, Christophe, da Silva Xavier, Gabriela, Rutter, Guy A.
Published 2016