Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication

by Chang, FuJung, Riera, Alberto, Evrin, Cecile, Sun, Jingchuan, Li, Huilin, Speck, Christian, Weinreich, Michael
Published 2015

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA

by Sun, Jingchuan, Evrin, Cecile, Samel, Stefan, Fernández-Cid, Alejandra, Riera, Alberto, Kawakami, Hironori, Stillman, Bruce, Speck, Christian, Li, Huilin
Published 2013

The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation

by Evrin, Cecile, Fernández-Cid, Alejandra, Riera, Alberto, Zech, Juergen, Clarke, Pippa, Herrera, M. Carmen, Tognetti, Silvia, Lurz, Rudi, Speck, Christian
Published 2014

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2–7 hexamer dimerization

by Evrin, Cecile, Fernández-Cid, Alejandra, Zech, Juergen, Herrera, M. Carmen, Riera, Alberto, Clarke, Pippa, Brill, Shlomo, Lurz, Rudi, Speck, Christian
Published 2013

A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome

by Simon, Aline C., Zhou, Jin C., Perera, Rajika L., van Deursen, Frederick, Evrin, Cecile, Ivanova, Marina E., Kilkenny, Mairi L., Renault, Ludovic, Kjaer, Svend, Matak-Vinković, Dijana, Labib, Karim, Costa, Alessandro, Pellegrini, Luca
Published 2014