PG545, a Heparan Sulfate Mimetic, Reduces Heparanase Expression In Vivo, Blocks Spontaneous Metastases and Enhances Overall Survival in the 4T1 Breast Carcinoma Model

by Hammond, Edward, Brandt, Ralf, Dredge, Keith
Published 2012

Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues☆

by Hammond, Edward, Handley, Paul, Dredge, Keith, Bytheway, Ian
Published 2013

The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics

by Hammond, Edward, Khurana, Ashwani, Shridhar, Viji, Dredge, Keith
Published 2014

The heparan sulfate mimetic PG545 interferes with Wnt/β-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine

by Jung, Deok-Beom, Yun, Miyong, Kim, Eun-Ok, Kim, Jaekwang, Kim, Bonglee, Jung, Ji Hoon, Wang, Enfeng, Mukhopadhyay, Debabrata, Hammond, Edward, Dredge, Keith, Shridhar, Viji, Kim, Sung-Hoon
Published 2014

HSulf-1 deficiency dictates a metabolic reprograming of glycolysis and TCA cycle in ovarian cancer

by Mondal, Susmita, Roy, Debarshi, Camacho-Pereira, Juliana, Khurana, Ashwani, Chini, Eduardo, Yang, Lifeng, Baddour, Joelle, Stilles, Katherine, Padmabandu, Seth, Leung, Sam, Kalloger, Steve, Gilks, Blake, Lowe, Val, Dierks, Thomas, Hammond, Edward, Dredge, Keith, Nagrath, Deepak, Shridhar, Viji
Published 2015