A Simple Method for Discovering Druggable, Specific Glycosaminoglycan-Protein Systems. Elucidation of Key Principles from Heparin/Heparan Sulfate-Binding Proteins

by Sarkar, Aurijit, Desai, Umesh R.
Published 2015

Designing Allosteric Inhibitors of Factor XIa. Lessons from the Interactions of Sulfated Pentagalloylglucopyranosides

by Al-Horani, Rami A., Desai, Umesh R.
Published 2014

On the Specificity of Heparin/Heparan Sulfate Binding to Proteins. Anion-Binding Sites on Antithrombin and Thrombin Are Fundamentally Different

by Mosier, Philip D., Krishnasamy, Chandravel, Kellogg, Glen E., Desai, Umesh R.
Published 2012

Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile

by Al-Horani, Rami A., Karuturi, Rajesh, Lee, Michael, Afosah, Daniel K., Desai, Umesh R.
Published 2016

Allosteric Partial Inhibition of Monomeric Proteases. Sulfated Coumarins Induce Regulation, not just Inhibition, of Thrombin

by Verespy III, Stephen, Mehta, Akul Y., Afosah, Daniel, Al-Horani, Rami A., Desai, Umesh R.
Published 2016

Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions

by Joseph, Prem Raj B., Mosier, Philip D., Desai, Umesh R., Rajarathnam, Krishna
Published 2015

Crystal Structures of Influenza A Virus Matrix Protein M1: Variations on a Theme

by Safo, Martin K., Musayev, Faik N., Mosier, Philip D., Zhou, Qibing, Xie, Hang, Desai, Umesh R.
Published 2014

Allosteric Inhibition of Human Factor XIa: Discovery of Monosulfated Benzofurans as a Class of Promising Inhibitors

by Argade, Malaika D., Mehta, Akul Y., Sarkar, Aurijit, Desai, Umesh R.
Published 2014

6-Hydroxyflavone and Derivatives Exhibit Potent Anti-Inflammatory Activity among Mono-, Di- and Polyhydroxylated Flavones in Kidney Mesangial Cells

by Wang, Xing, Wang, Zhiwei, Sidhu, Preetpal Singh, Desai, Umesh R., Zhou, Qibing
Published 2015

Targeting the GPIbα Binding Site of Thrombin To Simultaneously Induce Dual Anticoagulant and Antiplatelet Effects

by Mehta, Akul Y., Thakkar, Jay N., Mohammed, Bassem M., Martin, Erika J., Brophy, Donald F., Kishimoto, Takao, Desai, Umesh R.
Published 2014

Synthetic, Non-saccharide, Glycosaminoglycan Mimetics Selectively Target Colon Cancer Stem Cells

by Patel, Nirmita J., Karuturi, Rajesh, Al-Horani, Rami A., Baranwal, Somesh, Patel, Jagrut, Desai, Umesh R., Patel, Bhaumik B.
Published 2014

Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1

by Mosier, Philip D., Chiang, Meng-Jung, Lin, Zhengshi, Gao, Yamei, Althufairi, Bashayer, Zhou, Qibing, Musayev, Faik, Safo, Martin K., Xie, Hang, Desai, Umesh R.
Published 2016