Cell death programs in Yersinia immunity and pathogenesis

by Philip, Naomi H., Brodsky, Igor E.
Published 2012

A Yersinia Effector with Enhanced Inhibitory Activity on the NF-κB Pathway Activates the NLRP3/ASC/Caspase-1 Inflammasome in Macrophages

by Zheng, Ying, Lilo, Sarit, Brodsky, Igor E., Zhang, Yue, Medzhitov, Ruslan, Marcu, Kenneth B., Bliska, James B.
Published 2011

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

by Brunette, Rebecca L., Young, Janet M., Whitley, Deborah G., Brodsky, Igor E., Malik, Harmit S., Stetson, Daniel B.
Published 2012

TLR signaling augments macrophage bactericidal activity through mitochondrial ROS

by West, A. Phillip, Brodsky, Igor E., Rahner, Christoph, Woo, Dong Kyun, Erdjument-Bromage, Hediye, Tempst, Paul, Walsh, Matthew C., Choi, Yongwon, Shadel, Gerald S., Ghosh, Sankar
Published 2011

Differential Induction of TLR3-Dependent Innate Immune Signaling by Closely Related Parasite Species

by Beiting, Daniel P., Peixoto, Lucia, Akopyants, Natalia S., Beverley, Stephen M., Wherry, E. John, Christian, David A., Hunter, Christopher A., Brodsky, Igor E., Roos, David S.
Published 2014

IQGAP1 Is Important for Activation of Caspase-1 in Macrophages and Is Targeted by Yersinia pestis Type III Effector YopM

by Chung, Lawton K., Philip, Naomi H., Schmidt, Valentina A., Koller, Antonius, Strowig, Till, Flavell, Richard A., Brodsky, Igor E., Bliska, James B.
Published 2014

Inflammasome Activation in Response to the Yersinia Type III Secretion System Requires Hyperinjection of Translocon Proteins YopB and YopD

by Zwack, Erin E., Snyder, Annelise G., Wynosky-Dolfi, Meghan A., Ruthel, Gordon, Philip, Naomi H., Marketon, Melanie M., Francis, Matthew S., Bliska, James B., Brodsky, Igor E.
Published 2015

Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol

by Casson, Cierra N., Copenhaver, Alan M., Zwack, Erin E., Nguyen, Hieu T., Strowig, Till, Javdan, Bahar, Bradley, William P., Fung, Thomas C., Flavell, Richard A., Brodsky, Igor E., Shin, Sunny
Published 2013

Oxidative metabolism enables Salmonella evasion of the NLRP3 inflammasome

by Wynosky-Dolfi, Meghan A., Snyder, Annelise G., Philip, Naomi H., Doonan, Patrick J., Poffenberger, Maya C., Avizonis, Daina, Zwack, Erin E., Riblett, Amber M., Hu, Baofeng, Strowig, Till, Flavell, Richard A., Jones, Russell G., Freedman, Bruce D., Brodsky, Igor E.
Published 2014

Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death

by Philip, Naomi H., DeLaney, Alexandra, Peterson, Lance W., Santos-Marrero, Melanie, Grier, Jennifer T., Sun, Yan, Wynosky-Dolfi, Meghan A., Zwack, Erin E., Hu, Baofeng, Olsen, Tayla M., Rongvaux, Anthony, Pope, Scott D., López, Carolina B., Oberst, Andrew, Beiting, Daniel P., Henao-Mejia, Jorge, Brodsky, Igor E.
Published 2016