Phosphorylation of Akt and ERK1/2 Is Required for VEGF-A/VEGFR2-Induced Proliferation and Migration of Lymphatic Endothelium

by Dellinger, Michael T., Brekken, Rolf A.
Published 2011

SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-β1 activity

by Rivera, Lee B., Brekken, Rolf A.
Published 2011

Stromal TGFβR2 signaling: a gateway to progression for pancreatic cancer

by Hagopian, Moriah M, Brekken, Rolf A
Published 2014

VEGF and Pleiotrophin Modulate the Immune Profile of Breast Cancer

by Lynn, Kristi D., Roland, Christina L., Brekken, Rolf A.
Published 2010

Phosphatidylserine-targeting antibody induces M1 macrophage polarization, promotes myeloid derived suppressor cell differentiation and boosts tumor-specific immunity

by Huang, Xianming, Yin, Yi, Ye, Dan, Brekken, Rolf, Thorpe, Philip
Published 2013

Vascular Endothelial Growth Factor Receptor-2 Promotes the Development of the Lymphatic Vasculature

by Dellinger, Michael T., Meadows, Stryder M., Wynne, Katherine, Cleaver, Ondine, Brekken, Rolf A.
Published 2013

Identification of lipid-phosphatidylserine (PS) as the target of unbiasedly selected cancer specific peptide-peptoid hybrid PPS1

by Desai, Tanvi J., Toombs, Jason E., Minna, John D., Brekken, Rolf A., Udugamasooriya, Damith Gomika
Published 2016

Enhanced Heme Function and Mitochondrial Respiration Promote the Progression of Lung Cancer Cells

by Hooda, Jagmohan, Cadinu, Daniela, Alam, Md Maksudul, Shah, Ajit, Cao, Thai M., Sullivan, Laura A., Brekken, Rolf, Zhang, Li
Published 2013

Targeting phosphatidylserine synergizes with immune checkpoint blockade by inducing de novo tumor specific immunity

by Huang, Xianming, Gong, Jian, Ye, Dan, Nguyen, Van, Gray, Michael, King, Steven, Hutchins, Jeff, Brekken, Rolf, Freimark, Bruce
Published 2015

Correlative studies of a Phase II clinical study of bavituximab and sorafenib in patients with advanced hepatocellular carcinoma

by Yopp, Adam, Kallinteris, Nikoletta, Huang, Xianming, Shan, Joe, Menander, Kerstin, Hutchins, Jeff, King, Steve, Xu, Xiaowei, Gabrilovich, Dmitry, Brekken, Rolf
Published 2014

Losartan Slows Pancreatic Tumor Progression and Extends Survival of SPARC-Null Mice by Abrogating Aberrant TGFβ Activation

by Arnold, Shanna A., Rivera, Lee B., Carbon, Juliet G., Toombs, Jason E., Chang, Chi-Lun, Bradshaw, Amy D., Brekken, Rolf A.
Published 2012

Antibody-mediated blockade of phosphatidylserine enhances the anti-tumor activity of targeted therapy and immune checkpoint inhibitors by affecting myeloid and lymphocyte populatio...

by Yopp, Adam, Kallinteris, Nikoletta, Huang, Xianming, Shan, Joe, Menander, Kerstin, Freimark, Bruce, Hutchins, Jeff, King, Steve, Gabrilovich, Dmitry I, Brekken, Rolf
Published 2014

Antibody-mediated phosphatidylserine blockade significantly enhances the efficacy of downstream immune checkpoint inhibition in K1735 mouse melanoma

by Huang, Xianming, Gong, Jian, Ye, Dan, Nguyen, Van, Yin, Shen, Archer, Rich, Hughes, Chris, Brekken, Rolf, Hutchins, Jeff, Schroit, Alan, Freimark, Bruce
Published 2014

Inhibition of VEGFR-2 Reverses Type 1 Diabetes in NOD Mice by Abrogating Insulitis and Restoring Islet Function

by Villalta, S. Armando, Lang, Jiena, Kubeck, Samantha, Kabre, Beniwende, Szot, Gregory L., Calderon, Boris, Wasserfall, Clive, Atkinson, Mark A., Brekken, Rolf A., Pullen, Nick, Arch, Robert H., Bluestone, Jeffrey A.
Published 2013

Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors

by Wang, Zhen, Bian, Huan, Bartual, Sergio G., Du, Wenting, Luo, Jinfeng, Zhao, Hu, Zhang, Shasha, Mo, Cheng, Zhou, Yang, Xu, Yong, Tu, Zhengchao, Ren, Xiaomei, Lu, Xiaoyun, Brekken, Rolf A., Yao, Libo, Bullock, Alex N., Su, Jin, Ding, Ke
Published 2016

A rapid in vivo screen for pancreatic ductal adenocarcinoma therapeutics

by Ocal, Ozhan, Pashkov, Victor, Kollipara, Rahul K., Zolghadri, Yalda, Cruz, Victoria H., Hale, Michael A., Heath, Blake R., Artyukhin, Alex B., Christie, Alana L., Tsoulfas, Pantelis, Lorens, James B., Swift, Galvin H., Brekken, Rolf A., Wilkie, Thomas M.
Published 2015

Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B

by Potts, Malia B., McMillan, Elizabeth A., Rosales, Tracy I., Kim, Hyun Seok, Ou, Yi-Hung, Toombs, Jason E., Brekken, Rolf A., Minden, Mark D., MacMillan, John B., White, Michael A.
Published 2015

Vascular channels formed by subpopulations of PECAM1+ melanoma cells

by Dunleavey, James M., Xiao, Lin, Thompson, Joshua, Kim, Mi Mi, Shields, Janiel M., Shelton, Sarah E., Irvin, David M., Brings, Victoria E., Ollila, David, Brekken, Rolf A., Dayton, Paul A., Melero-Martin, Juan M., Dudley, Andrew C.
Published 2014

Combined VEGF and CXCR4 antagonism targets the GBM stem cell population and synergistically improves survival in an intracranial mouse model of glioblastoma

by Barone, Amy, Sengupta, Rajarshi, Warrington, Nicole M., Smith, Erin, Wen, Patrick Y., Brekken, Rolf A., Romagnoli, Barbara, Douglas, Garry, Chevalier, Eric, Bauer, Michael P., Dembowsky, Klaus, Piwnica-Worms, David, Rubin, Joshua B.
Published 2014

Identification of a Monoclonal Antibody That Attenuates Antiphospholipid Syndrome-Related Pregnancy Complications and Thrombosis

by Mineo, Chieko, Lanier, Lane, Jung, Eunjeong, Sengupta, Samarpita, Ulrich, Victoria, Sacharidou, Anastasia, Tarango, Cristina, Osunbunmi, Olutoye, Shen, Yu-Min, Salmon, Jane E., Brekken, Rolf A., Huang, Xianming, Thorpe, Philip E., Shaul, Philip W.
Published 2016