rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    non sort: The
    title: effects of kisspeptin-54 on reproductive functions in paraquat-exposed adult male and female rats
  name:
    name part: Anuar Md. Zain
    role:
      role term: creator
    role:
      role term: author
  name:
    name part: Universiti Sultan Zainal Abidin
    name part: Faculty of Medicine
  type of resource: text
  genre: Dissertations, Academic
  origin info:
    place:
      place term: my
    date issued: 2016
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: print
    extent: xxvi, 237 leaves : some colour illustrations ; 30 cm.
  abstract: Kisspeptin (KP) has been recognized as a crucial regulator of the onset of puberty, the regulation of sex hormone-mediated secretion of gonadotrophins, and the control of fertility. Thus, the present study was aimed to investigate the potential roles of KP-S4 in modulating the reproductive adverse effects caused by Paraquat (PQ) exposure in rats. A total of SO male and SO female adult Sprague-Dawley rats were used in the present study. Rats were randomly divided into two groups; (i) PQ (n= 40) and (ii) normal saline, PQ- (n= 10) for a period of 30 days. All PQ treated rats were given 13mg/kg of PQ intraperitoneal for 30days (LDso for femaJe rat j 26mgi/kg; i .. ) and l2.Smg/kg of PQ in male rats (LDso for male rat i 2Smg/kg). The rats that received intraperitoneal PQ were further divided into four groups (n= 10 per group) (i) untreated PQ-exposed (PQ+) (ii) PQ-exposed rats treated with low dose of KP-S4 (PQ/KP low; 1 pg/kg) (iii) PQ-exposed rats treated with interm diate dose of KP-S4 (PQ/KP intermediate; lng/kg) (iv) PQ-exposed rats treated with high dose of KP-S4 (PQ/KP high; 1 ug/kg). Male rats were sacrificed after seven days of KP-S4 treatment. Serum was used for hormonal assays i.e. FSH, LH, PRL, inhibin B, testosterone and tissues were subjected for histopathology, and testicular tissues were subjected for measurement of enzymes and oxidative markers, and the epididymis sperms were used for sperm assays. For female rats, daily vagina smear was conducted for 32 days starting from Day 1 KP-S4 treatment. After sacrifice, the serum was used for hormonal assays i.e. FSH, LH, PRL, inhibin B, estradiol and progesterone, and tissues were subjected for histopathology and pregnancy outcome, and ovarian tissues were subjected for measurement of oxidative markers. In the present study, both male and female reproductive functions were affected by subchronic PQ exposure. Findings from the present study confirmed the adverse effects of PQ leading to reduced reproductive org…
  note: Anuar Md. Zain
  note: Thesis (Degree of Doctor of Philosophy) - Universiti Sultan Zainal Abidin, 2016
  note: Includes bibliographical references (pages 191-231)
  subject:
    name:
      name part: Universiti Sultan Zainal Abidin
    topic: Dissertations
  subject:
    name:
      name part: Universiti Sultan Zainal Abidin
    topic: Faculty of Medicine
    genre: Dissertations
  subject:
    topic: Kisspeptin neurons
  subject:
    topic: Kisspeptins
  subject:
    topic: Paraquat
  subject:
    topic: Reproductive health
  classification: RA788 .A58 2016
  classification: WA 240 A636e 2016
  record info:
    record content source: UniSZA
    record creation date: 170802
    record change date: 20201223093000.0
    record identifier: 0000093627