Human-based systems for translational research
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Cambridge :
The Royal Society of Chemistry ,
2015
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| Series: | RSC drug discovery series
no. 41 |
| Subjects: |
Table of Contents:
- 1. Access to human cells and tissues
- 2. Functional studies with human isolated tissues to better predict clinical safety and efficacy
- 3. Translational research in pharmacology and toxicology using precision-cut tissue slices
- 4. Modelling the human respiratory system: Approaches for in vitro safety testing and drug discovery
- 5. Complex primary human cell systems for drug discovery
- 6. Human in vitro ADMET and prediction of human pharmacokinetics and toxicity liabilities at the discovery stage
- 7. Body-on-a-chip technology and suporting
- 8. Utility of human stem cells for drug discovery
- 9. In silico solutions for predicting efficacy and toxicity
- 10. In silico organ modelling in predicting efficacy and safety of new medicines
- 11. Human microdosing/phase 0 studies to accelerate drug development