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00000cam a2200000 7i4500 |
| 001 |
0000092130 |
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20171009093000.0 |
| 008 |
170601s2015 -uk eng |
| 020 |
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|a 9781849731867
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| 050 |
0 |
0 |
|a RM301.25
|b .I56 2015
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| 060 |
1 |
0 |
|a QV 745
|b .I64 2015
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| 090 |
0 |
0 |
|a RM301.25
|b .I56 2015
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| 245 |
0 |
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|a Ion channel drug discovery
|c Brian Cox and Martin Gosling
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| 260 |
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|a Cambridge :
|b Royal Society of Chemistry ,
|c c2015
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| 300 |
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|a xviii, 366 p. :
|b ill.(some col.) ;
|c 25 cm.
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| 440 |
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|a RSC drug discovery series 39
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| 504 |
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|a Includes bibliographical references and index
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| 505 |
0 |
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|a 1. Ion channel drug discovery: a historical perspective -- 2. High throughput screening -- 3. Automated electrophysiology in ion channel drug discovery -- 4. Structural understanding of ion channels in atomic detail -- 5. Voltages-gated Sodium Channels: structure, function, and molecular pharmacology -- 6. AMPA receptor positive allosteric modulators- a case history -- 7. The discovery of novel inhaled ENaC blockers for the treatment of cystic fibrosis lung disease -- 8. The therapeutic potential of small-molecule modulators of the cystic fibrosis transmembrane conductance regulator (CFTR) CI channel -- 9. TRPV1 antagonism: from research to clinic -- 10. Open access to the KCNQ channel: Retigabine and second generation M-current openers -- 11. The therapeutic potential of hERG1 K channels for treating cancer and cardiac arrhythmias -- 12. Does nature do Ion channel drug discovery better than us? -- 13. Antibodies as Ion channel modulators -- 14. Ion channel drug discovery: future perspectives
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| 650 |
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0 |
|a Drug development
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| 650 |
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0 |
|a Drug Discovery
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| 650 |
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0 |
|a Ion Channels
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| 650 |
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0 |
|a Pharmacology, Experimental
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| 700 |
1 |
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|a Cox, Brian ,
|e author
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| 700 |
1 |
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|a Gosling, Martin ,
|e author
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| 999 |
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|a 1000169162
|b Book
|c OPEN SHELF (30 DAYS)
|e Tembila Campus
|