New horizons in predictive drug metabolism and pharmacokinetics
| Other Authors: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Cambridge :
Royal Society of Chemistry
c2016
|
| Series: | RSC drug discovery series
no 49 |
| Subjects: |
Table of Contents:
- 1. How physicochemical properties of drugs affect their metabolism and clearance
- 2. Role of solubility, permeability and adsorption in drug discovery in development
- 3. Models for nonspecific binding and partitioning
- 4. Cytochrome P450 mediated drug metabolism
- 5. Non-cytochrome P450 enzymes and glucuronidation
- 6. Metabolite profiling
- 7. Application of humanised and other transgenic models to predict human responses to drugs
- 8. Stem cells and drug metabolism
- 9. Chemically reactive versus stable drug metabolites: Role in adverse drug reactions
- 10. Integrating metabolism and toxicity properties
- 11. Metabolomics-based approaches to determine drug metabolite profiles
- 12. Drug-drug ineteractions: regulatory and theoretical considerations, and an industrial perspective
- 13. Drug-drug interactions: Computational approaches
- 14. Induction of hepatic cytochrome P450 enzymes: Importance in drug development and toxicity
- 15. Current status and implications of transporters: QSAR analysis method to evaluate drug-drug interactions of human bile salt export pump (ABCB11/BSEP) and prediction of intrahepatic cholestasis risk
- 16. Formulation of optimizing bioavailability
- 17. Systems pharmacology modelling
- 18. Pharmacokinetic-pharmacodynamic modelling in drug development with special reference to oncology