Thermodynamics and kinetics of drug binding
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Weinheim, Germany :
Wiley-VCH ,
c2015
|
| Series: | Drug discovery in infectious diseases
volume 65 |
| Subjects: |
Table of Contents:
- 1. The binding thermodynamics of drug candidates
- 2. Van't hoff based thermodynamics
- 3. Computation of drug-binding thermodynamics
- 4. Thermodynamics-guided optimizations in medicinal chemistry
- 5. From molecular understanding to structure thermodynamic relationships, the case of acetylcholine binding proteins
- 6. Thermodynamics in lead optimization
- 7. Thermodynamic profiling of carbonic anhydrase inhibitors
- 8. Drug target residence time
- 9. Experimental methods to determine binding kinetics
- 10. Challenges in the medicinal chemical optimization of binding kinetics
- 11. Computational approaches for studying drug binding kinetics
- 12. The use of structural information to understand binding kinetics
- 13. Importance of drug target residence time at G protein-coupled receptors a case for the adenosine receptors
- 14. Case study: angiotensin receptor Blockers (ARBs)
- 15. The Kinetics and Thermodynamics of Staphylococcus aureus fabI inhibition
- 16. Thermodynamics and binding kinetics in drug discovery