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170530s2015 gw eng |
| 020 |
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|a 9783527335824
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| 020 |
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|a 9783527673025
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| 020 |
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|a 9783527673032
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|a 9783527673049
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| 020 |
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|a 9783527673056
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| 050 |
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|a RM301.25
|b .T44 2015
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| 060 |
1 |
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|a QV 744
|b .T411 2015
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| 090 |
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|a RM301.25
|b .T44 2015
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| 245 |
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|a Thermodynamics and kinetics of drug binding
|c edited by Gyorgy M. Keseru, David C. Swinney
|
| 260 |
|
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|a Weinheim, Germany :
|b Wiley-VCH ,
|c c2015
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| 300 |
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|a Vol. 65, xxiii, 334 p. :
|b ill (some col.) ;
|c 25 cm.
|
| 440 |
|
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|a Drug discovery in infectious diseases
|v volume 65
|
| 504 |
|
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|a Includes bibliographical references and index
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| 505 |
0 |
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|a 1. The binding thermodynamics of drug candidates -- 2. Van't hoff based thermodynamics -- 3. Computation of drug-binding thermodynamics -- 4. Thermodynamics-guided optimizations in medicinal chemistry -- 5. From molecular understanding to structure thermodynamic relationships, the case of acetylcholine binding proteins -- 6. Thermodynamics in lead optimization -- 7. Thermodynamic profiling of carbonic anhydrase inhibitors -- 8. Drug target residence time -- 9. Experimental methods to determine binding kinetics -- 10. Challenges in the medicinal chemical optimization of binding kinetics -- 11. Computational approaches for studying drug binding kinetics -- 12. The use of structural information to understand binding kinetics -- 13. Importance of drug target residence time at G protein-coupled receptors a case for the adenosine receptors -- 14. Case study: angiotensin receptor Blockers (ARBs) -- 15. The Kinetics and Thermodynamics of Staphylococcus aureus fabI inhibition -- 16. Thermodynamics and binding kinetics in drug discovery
|
| 650 |
|
0 |
|a Binding sites
|x Thermodynamics
|
| 650 |
|
0 |
|a Drug development
|
| 650 |
|
0 |
|a Pharmacokinetics
|
| 700 |
1 |
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|a Keseru, Gyorgy M. ,
|e author
|
| 700 |
1 |
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|a Swinney, David C. ,
|e author
|
| 999 |
|
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|a 1000169199
|b Book
|c OPEN SHELF (30 DAYS)
|e Tembila Campus
|